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Cellosaurus V79MZ (CVCL_4V36)

[Text version]
Cell line name V79MZ
Synonyms V79-MZ; V79-Mz; V79 Mainz; V79d MZ
Accession CVCL_4V36
Resource Identification Initiative To cite this cell line use: V79MZ (RRID:CVCL_4V36)
Comments Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_2234 (V79)
Children:
CVCL_4V37 (V79-hCYP1A1)CVCL_4V39 (V79-hCYP1A2)CVCL_A2GU (V79-hCYP2E1)
CVCL_A2GW (V79-hSULT1A1)CVCL_A2GX (V79-hSULT1A3)CVCL_A2GV (V79-hSULT2A1)
CVCL_GR62 (V79-rCYP1A1)CVCL_GR63 (V79-rCYP1A2)CVCL_GR60 (V79-rCYP2B1)
CVCL_B5WP (V79MZh1B1)CVCL_4709 (V79MZh11B1)CVCL_4710 (V79MZh11B2)
CVCL_GR61 (XEM1)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=1446722; DOI=10.1016/0926-6917(92)90017-7
Wolfel C., Heinrich-Hirsch B., Schulz-Schalge T., Seidel A., Frank H., Ramp U., Wachter F., Wiebel F.J., Gonzalez F.J., Greim H., Doehmer J.
Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2.
Eur. J. Pharmacol. 228:95-102(1992)

PubMed=8236270; DOI=10.1016/0300-483x(93)90063-x
Doehmer J.
V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies.
Toxicology 82:105-118(1993)

PubMed=8293790; DOI=10.1016/0926-6917(93)90052-R
Schmalix W.A., Maser H., Kiefer F., Reen R., Wiebel F.J., Gonzalez F.J., Seidel A., Glatt H.-R., Greim H., Doehmer J.
Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.
Eur. J. Pharmacol. 248:251-261(1993)

PubMed=7588408; DOI=10.3109/07435809509030460
Denner K., Doehmer J., Bernhardt R.
Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 Chinese hamster cells.
Endocr. Res. 21:443-448(1995)

PubMed=8596476; DOI=10.1093/mutage/10.6.549
Ellard S., James S.A., Parry E.M., Parry J.M.
A genetically engineered V79 cell line SD1 expressing rat CYP2B1 exhibits chromosomal instability at the integration site of the transfected DNA.
Mutagenesis 10:549-554(1995)

PubMed=9625737; DOI=10.1021/tx970236p
Luch A., Coffing S.L., Tang Y.M., Schneider A., Soballa V., Greim H., Jefcoate C.R., Seidel A., Greenlee W.F., Baird W.M., Doehmer J.
Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
Chem. Res. Toxicol. 11:686-695(1998)

PubMed=10474822; DOI=10.1093/mutage/14.1.57
Simi S., Xiao Y., Campagna M., Doehmer J., Darroudi F.
Dual-colour FISH analysis to characterize a marker chromosome in cytochrome P450 2B1 recombinant V79 Chinese hamster cells.
Mutagenesis 14:57-61(1999)

PubMed=10657971; DOI=10.1093/carcin/21.2.295
Kreis P., Brandner S., Coughtrie M.W.H., Pabel U., Meinl W., Glatt H.-R., Andrae U.
Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant.
Carcinogenesis 21:295-299(2000)

PubMed=18616954; DOI=10.1016/j.mrfmmm.2008.06.003
Liu Y.-G., Glatt H.-R.
Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes.
Mutat. Res. 643:64-69(2008)

PubMed=31112310; DOI=10.1002/em.22309
Zhu N., Hu K.-Q., Li Z.-H., Chen Y.-T., Liu Y.-G.
Micronuclei formation by promutagens in metabolism-incompetent V79 cells interacting with activation-proficient cells in various experimental settings.
Environ. Mol. Mutagen. 61:224-234(2020)

PubMed=33035519; DOI=10.1016/j.cbi.2020.109283
Yu H., Li Z.-H., Yang Z.-Y., Song M.-Q., Liu Y.-G.
1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1.
Chem. Biol. Interact. 332:109283.1-109283.8(2020)

Cross-references
Encyclopedic resources Wikidata; Q54992625
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number11