ID   V79MZ
AC   CVCL_4V36
SY   V79-MZ; V79-Mz; V79 Mainz; V79d MZ
DR   Wikidata; Q54992625
RX   PubMed=1446722;
RX   PubMed=7588408;
RX   PubMed=8236270;
RX   PubMed=8293790;
RX   PubMed=8596476;
RX   PubMed=9625737;
RX   PubMed=10474822;
RX   PubMed=10657971;
RX   PubMed=18616954;
RX   PubMed=31112310;
RX   PubMed=33035519;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_2234 ! V79
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 11
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RX   PubMed=1446722; DOI=10.1016/0926-6917(92)90017-7;
RA   Wolfel C., Heinrich-Hirsch B., Schulz-Schalge T., Seidel A., Frank H.,
RA   Ramp U., Wachter F., Wiebel F.J., Gonzalez F.J., Greim H., Doehmer J.;
RT   "Genetically engineered V79 Chinese hamster cells for stable
RT   expression of human cytochrome P450IA2.";
RL   Eur. J. Pharmacol. 228:95-102(1992).
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RX   PubMed=7588408; DOI=10.3109/07435809509030460;
RA   Denner K., Doehmer J., Bernhardt R.;
RT   "Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their
RT   functional expression in COS-7 and V79 Chinese hamster cells.";
RL   Endocr. Res. 21:443-448(1995).
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RX   PubMed=8236270; DOI=10.1016/0300-483x(93)90063-x;
RA   Doehmer J.;
RT   "V79 Chinese hamster cells genetically engineered for cytochrome P450
RT   and their use in mutagenicity and metabolism studies.";
RL   Toxicology 82:105-118(1993).
//
RX   PubMed=8293790; DOI=10.1016/0926-6917(93)90052-R;
RA   Schmalix W.A., Maser H., Kiefer F., Reen R., Wiebel F.J.,
RA   Gonzalez F.J., Seidel A., Glatt H.-R., Greim H., Doehmer J.;
RT   "Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese
RT   hamster cells and metabolic activation of benzo[a]pyrene.";
RL   Eur. J. Pharmacol. 248:251-261(1993).
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RX   PubMed=8596476; DOI=10.1093/mutage/10.6.549;
RA   Ellard S., James S.A., Parry E.M., Parry J.M.;
RT   "A genetically engineered V79 cell line SD1 expressing rat CYP2B1
RT   exhibits chromosomal instability at the integration site of the
RT   transfected DNA.";
RL   Mutagenesis 10:549-554(1995).
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RX   PubMed=9625737; DOI=10.1021/tx970236p;
RA   Luch A., Coffing S.L., Tang Y.M., Schneider A., Soballa V., Greim H.,
RA   Jefcoate C.R., Seidel A., Greenlee W.F., Baird W.M., Doehmer J.;
RT   "Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster
RT   cells and metabolically catalyzed DNA adduct formation of
RT   dibenzo[a,l]pyrene.";
RL   Chem. Res. Toxicol. 11:686-695(1998).
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RX   PubMed=10474822; DOI=10.1093/mutage/14.1.57;
RA   Simi S., Xiao Y., Campagna M., Doehmer J., Darroudi F.;
RT   "Dual-colour FISH analysis to characterize a marker chromosome in
RT   cytochrome P450 2B1 recombinant V79 Chinese hamster cells.";
RL   Mutagenesis 14:57-61(1999).
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RX   PubMed=10657971; DOI=10.1093/carcin/21.2.295;
RA   Kreis P., Brandner S., Coughtrie M.W.H., Pabel U., Meinl W.,
RA   Glatt H.-R., Andrae U.;
RT   "Human phenol sulfotransferases hP-PST and hM-PST activate propane
RT   2-nitronate to a genotoxicant.";
RL   Carcinogenesis 21:295-299(2000).
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RX   PubMed=18616954; DOI=10.1016/j.mrfmmm.2008.06.003;
RA   Liu Y.-G., Glatt H.-R.;
RT   "Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line
RT   expressing two human biotransformation enzymes.";
RL   Mutat. Res. 643:64-69(2008).
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RX   PubMed=31112310; DOI=10.1002/em.22309;
RA   Zhu N., Hu K.-Q., Li Z.-H., Chen Y.-T., Liu Y.-G.;
RT   "Micronuclei formation by promutagens in metabolism-incompetent V79
RT   cells interacting with activation-proficient cells in various
RT   experimental settings.";
RL   Environ. Mol. Mutagen. 61:224-234(2020).
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RX   PubMed=33035519; DOI=10.1016/j.cbi.2020.109283;
RA   Yu H., Li Z.-H., Yang Z.-Y., Song M.-Q., Liu Y.-G.;
RT   "1-Methylpyrene induces chromosome loss and mitotic apparatus damage
RT   in a Chinese hamster V79-derived cell line expressing both human
RT   CYP1A2 and sulfotransferase 1A1.";
RL   Chem. Biol. Interact. 332:109283.1-109283.8(2020).
//