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Cellosaurus V79MZh2D6*17 (CVCL_F0FM)

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Cell line name V79MZh2D6*17
Accession CVCL_F0FM
Resource Identification Initiative To cite this cell line use: V79MZh2D6*17 (RRID:CVCL_F0FM)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2450.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2625; CYP2D6 (Note=With p.Thr107Ile (c.320C>T) and p.Arg296Cys (c.886C>T). Allele CYP2D6*17).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4V36 (V79MZ)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=12947487
Niels Krebsfaenger, Thomas E. Murdter, Ulrich M. Zanger, Michel F. Eichelbaum, Johannes Doehmer;
V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.
ALTEX 20:143-154(2003)

Patent=US20050130116
Johannes Doehmer, Niels Krebsfaenger, Michel F. Eichelbaum, Ulrich M. Zanger;
Stable expression of polymorphous forms of human cytochrome p450 2D6.
Patent number US20050130116, 16-Jun-2005

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1