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Cellosaurus V79MZh3A4/hOR-1 (CVCL_F0FC)

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Cell line name V79MZh3A4/hOR-1
Synonyms V79MZh3A4hOR-1; V79MZh3A4-hOR; V79MZ-h3A4-CYPhOR
Accession CVCL_F0FC
Resource Identification Initiative To cite this cell line use: V79MZh3A4/hOR-1 (RRID:CVCL_F0FC)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2637; CYP3A4.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:9208; POR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4V36 (V79MZ)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=8806738; DOI=10.1006/abbi.1996.0345
Anneliese Schneider, Wolfgang A. Schmalix, Vasanthi Siruguri, Els M. de Groene, G. Jean Horbach, Britta Kleingeist, Dieter Lang, Ronald Bocker, Claire Belloc, Philippe Beaune, Helmut Greim, Johannes Doehmer;
Stable expression of human cytochrome P450 3A4 in conjunction with human NADPH-cytochrome P450 oxidoreductase in V79 Chinese hamster cells.
Arch. Biochem. Biophys. 332:295-304(1996)

PubMed=20654528; DOI=10.1016/s0887-2333(99)00020-x
Rolf Gebhardt, Caroline Lippert, Anneliese Schneider, Johannes Doehmer;
Improved determination of drug metabolism by perifusion of recombinant V79 cells carrying human CYP3A4.
Toxicol. In Vitro 13:639-643(1999)

PubMed=12947487
Niels Krebsfaenger, Thomas E. Murdter, Ulrich M. Zanger, Michel F. Eichelbaum, Johannes Doehmer;
V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.
ALTEX 20:143-154(2003)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1