ID   V79MZh3A4/hOR-1
AC   CVCL_F0FC
SY   V79MZh3A4hOR-1; V79MZh3A4-hOR; V79MZ-h3A4-CYPhOR
RX   PubMed=8806738;
RX   PubMed=12947487;
RX   PubMed=20654528;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2637; CYP3A4.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:9208; POR.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_4V36 ! V79MZ
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 14-08-25; Last updated: 14-08-25; Version: 1
//
RX   PubMed=8806738; DOI=10.1006/abbi.1996.0345;
RA   Schneider, Anneliese
RA   Schmalix, Wolfgang A.
RA   Siruguri, Vasanthi
RA   de Groene, Els M.
RA   Horbach, G. Jean
RA   Kleingeist, Britta
RA   Lang, Dieter
RA   Bocker, Ronald
RA   Belloc, Claire
RA   Beaune, Philippe
RA   Greim, Helmut
RA   Doehmer, Johannes
RT   "Stable expression of human cytochrome P450 3A4 in conjunction with
RT   human NADPH-cytochrome P450 oxidoreductase in V79 Chinese hamster
RT   cells.";
RL   Arch. Biochem. Biophys. 332:295-304(1996).
//
RX   PubMed=12947487;
RA   Krebsfaenger, Niels
RA   Murdter, Thomas E.
RA   Zanger, Ulrich M.
RA   Eichelbaum, Michel F.
RA   Doehmer, Johannes
RT   "V79 Chinese hamster cells genetically engineered for polymorphic
RT   cytochrome P450 2D6 and their predictive value for humans.";
RL   ALTEX 20:143-154(2003).
//
RX   PubMed=20654528; DOI=10.1016/s0887-2333(99)00020-x;
RA   Gebhardt, Rolf
RA   Lippert, Caroline
RA   Schneider, Anneliese
RA   Doehmer, Johannes
RT   "Improved determination of drug metabolism by perifusion of
RT   recombinant V79 cells carrying human CYP3A4.";
RL   Toxicol. In Vitro 13:639-643(1999).
//