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Cellosaurus V79MZr1A1 (CVCL_GR62)

[Text version]
Cell line name V79MZr1A1
Synonyms V79-rCYP1A1; V79-XEM2; XEM2
Accession CVCL_GR62
Resource Identification Initiative To cite this cell line use: V79MZr1A1 (RRID:CVCL_GR62)
Comments Karyotypic information: 22,X,-5,+5q (PubMed=10474822).
Genetic integration: Method=Transfection; Gene=RGD; 2458; Cyp1a1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4V36 (V79MZ)
Children:
CVCL_F0FA (V79MZr1A1/hGSTP1-33)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=1692605; DOI=10.1016/S0026-895X(25)10890-0
Satish Dogra, Johannes Doehmer, Hans-Ruedolf Glatt, Horst Molders, Peter Siegert, Thomas Friedberg, Albrecht Seidel, Franz Oesch;
Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
Mol. Pharmacol. 37:608-613(1990)

PubMed=1800893; DOI=10.1093/mutage/6.6.461
Sian Ellard, Yaseen Mohammed, Satish Dogra, Catherine Wolfel, Johannes Doehmer, James M. Parry;
The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.
Mutagenesis 6:461-470(1991)

PubMed=1441600; DOI=10.3109/00498259209051863
Johannes Doehmer, Catherine Wolfel, Satish Dogra, C. Doehmer, Albrecht Seidel, Karl-Ludwig Platt, Franz Oesch, Hans-Ruedolf Glatt;
Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1.
Xenobiotica 22:1093-1099(1992)

PubMed=8236270; DOI=10.1016/0300-483x(93)90063-x
Johannes Doehmer;
V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies.
Toxicology 82:105-118(1993)

PubMed=7565906; DOI=10.1016/0165-7992(95)00034-8
Silvana Simi, S. Morelli, Pier Giovanni Gervasi, Giuseppe Rainaldi;
Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes.
Mutat. Res. 347:151-156(1995)

PubMed=10335445; DOI=10.1081/dmr-100101928
Johannes Doehmer, Jeroen Titus Maria Buters, Andreas Luch, Volker J. Soballa, William M. Baird, Hilary Gonzalez Morrison, John Joseph Stegeman, Alan J. Townsend, William F. Greenlee, Hans-Ruedolf Glatt, Albrecht Seidel ...Show all 13 authors... , Juergen Jacob, Helmut Greim; Show fewer authors
Molecular studies on the toxifying effects by genetically engineered cytochromes P450.
Drug Metab. Rev. 31:423-435(1999)

PubMed=10474822; DOI=10.1093/mutage/14.1.57
Silvana Simi, Yun Xiao, Marcello Campagna, Johannes Doehmer, Firouz Darroudi;
Dual-colour FISH analysis to characterize a marker chromosome in cytochrome P450 2B1 recombinant V79 Chinese hamster cells.
Mutagenesis 14:57-61(1999)

DOI=10.1080/10406639908020586
Juergen Jacob, Gottfried Raab, Volker J. Soballa, Andreas Luch, Gernot Grimmer, Helmut Greim, Johannes Doehmer, Hilary Gonzalez Morrison, John Joseph Stegeman, Albrecht Seidel;
Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a, l]pyrene by various CYP450 isoforms.
Polycycl. Aromat. Compd. 16:191-203(2000)

PubMed=12947487
Niels Krebsfaenger, Thomas E. Murdter, Ulrich M. Zanger, Michel F. Eichelbaum, Johannes Doehmer;
V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.
ALTEX 20:143-154(2003)

PubMed=19330882; DOI=10.1016/j.cbi.2009.01.010; PMCID=PMC2744106
Sandra Leone-Kabler, Albrecht Seidel, Juergen Jacob, Johannes Doehmer, Charles S. Morrow, Alan J. Townsend;
Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
Chem. Biol. Interact. 179:240-246(2009)

Cross-references
Encyclopedic resources Wikidata; Q54994668
Entry history
Entry creation26-Sep-2016
Last entry update14-Aug-2025
Version number12