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Cellosaurus V79MZh2E1 (CVCL_A2GU)

[Text version]
Cell line name V79MZh2E1
Synonyms V79-hCYP2E1; V79h2E1
Accession CVCL_A2GU
Resource Identification Initiative To cite this cell line use: V79MZh2E1 (RRID:CVCL_A2GU)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2631; CYP2E1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4V36 (V79MZ)
Children:
CVCL_5A60 (V79MZh2E1/hSULT1A1)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

DOI=10.1016/0926-6917(95)00008-9
Wolfgang A. Schmalix, Martina Barrenscheen, Robert Landsiedel, Christine Janzowski, Gerhard Eisenbrand, Frank J. Gonzalez, Erik Eliasson, Magnus Ingelman-Sundberg, Monika Perchermeier, Helmut Greim, Johannes Doehmer;
Stable expression of human cytochrome P4502E1 in V79 Chinese hamster cells.
Eur. J. Pharmacol. 293:123-131(1995)

PubMed=10335445; DOI=10.1081/dmr-100101928
Johannes Doehmer, Jeroen Titus Maria Buters, Andreas Luch, Volker J. Soballa, William M. Baird, Hilary Gonzalez Morrison, John Joseph Stegeman, Alan J. Townsend, William F. Greenlee, Hans-Ruedolf Glatt, Albrecht Seidel ...Show all 13 authors... , Juergen Jacob, Helmut Greim; Show fewer authors
Molecular studies on the toxifying effects by genetically engineered cytochromes P450.
Drug Metab. Rev. 31:423-435(1999)

DOI=10.1080/10406639908020586
Juergen Jacob, Gottfried Raab, Volker J. Soballa, Andreas Luch, Gernot Grimmer, Helmut Greim, Johannes Doehmer, Hilary Gonzalez Morrison, John Joseph Stegeman, Albrecht Seidel;
Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a, l]pyrene by various CYP450 isoforms.
Polycycl. Aromat. Compd. 16:191-203(2000)

PubMed=12947487
Niels Krebsfaenger, Thomas E. Murdter, Ulrich M. Zanger, Michel F. Eichelbaum, Johannes Doehmer;
V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.
ALTEX 20:143-154(2003)

PubMed=16221041; DOI=10.1177/026119290303100104
Ulrike Bernauer, Hans-Ruedolf Glatt, Barbara Heinrich-Hirsch, Yun-Gang Liu, Eva Muckel, Barbel Vieth, Ursula Gundert-Remy;
Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1.
Altern. Lab. Anim. 31:21-30(2003)

Cross-references
Encyclopedic resources Wikidata; Q105511675
Entry history
Entry creation12-Jan-2021
Last entry update14-Aug-2025
Version number8