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Cellosaurus XEM1 (CVCL_GR61)

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Cell line name XEM1
Accession CVCL_GR61
Resource Identification Initiative To cite this cell line use: XEM1 (RRID:CVCL_GR61)
Comments Genetic integration: Method=Transfection/transduction; Gene=RGD; 2458; Cyp1a1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4V36 (V79MZ)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=1692605; DOI=10.1016/S0026-895X(25)10890-0
Satish Dogra, Johannes Doehmer, Hans-Ruedolf Glatt, Horst Molders, Peter Siegert, Thomas Friedberg, Albrecht Seidel, Franz Oesch;
Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
Mol. Pharmacol. 37:608-613(1990)

PubMed=1441600; DOI=10.3109/00498259209051863
Johannes Doehmer, Catherine Wolfel, Satish Dogra, C. Doehmer, Albrecht Seidel, Karl-Ludwig Platt, Franz Oesch, Hans-Ruedolf Glatt;
Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1.
Xenobiotica 22:1093-1099(1992)

PubMed=8236270; DOI=10.1016/0300-483x(93)90063-x
Johannes Doehmer;
V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies.
Toxicology 82:105-118(1993)

Cross-references
Encyclopedic resources Wikidata; Q54994667
Entry history
Entry creation26-Sep-2016
Last entry update14-Aug-2025
Version number11