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Cellosaurus LNCaP clone FGC (CVCL_1379)

[Text version]
Cell line name LNCaP clone FGC
Synonyms LNCaP-Clone-FGC; LNCaP.FGC; LNCaP-FGC; LNCaP FGC; LNCAPCLONEFGC; LNCaP-ATCC; LNCaP Fast Growing Colony
Accession CVCL_1379
Resource Identification Initiative To cite this cell line use: LNCaP clone FGC (RRID:CVCL_1379)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Doubling time: 43 hours (PubMed=15389782); ~34 hours (ATCC=CRL-1740); ~36 hours (PBCF); 38.71 hours (JWGray panel).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; SNP array analysis.
Misspelling: LNCaP.FCG; Note=Occasionally.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (Cosmic-CLP=907788; DepMap=ACH-000977).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (Cosmic-CLP=907788; DepMap=ACH-000977).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (Cosmic-CLP=907788; DepMap=ACH-000977).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (DepMap=ACH-000977).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.89
Native American0.31
East Asian, North0
East Asian, South2.4
South Asian8.61
European, North28.39
European, South57.41
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Children:
CVCL_C0BI (Abcam LNCaP clone FGC TMPRSS2 KO)CVCL_U984 (AILNCaP)CVCL_C0Z9 (JHU-LNCaP-SM)
CVCL_A1BN (LNCaP AR-NTD/pHage)CVCL_A1BM (LNCaP AR-V7/pHage)CVCL_A1BL (LNCaP AR-V7/pLenti)
CVCL_C8W7 (LNCaP Clone FGC-EGFP)CVCL_A4BQ (LNCaP clone FGC-Luc2)CVCL_W668 (LNCaP clone FGC.10)
CVCL_E7J8 (LNCaP clone FGC(Cas9))CVCL_B413 (LNCaP-17)CVCL_WW88 (LNCaP-19)
CVCL_B414 (LNCaP-34)CVCL_ZC87 (LNCaP-95)CVCL_ZX07 (LNCAP-AAR)
CVCL_4791 (LNCaP-AI)CVCL_C7XA (LNCaP-AR)CVCL_F0L7 (LNCaP-BicR)
CVCL_5J30 (LNCaP-luc-M6)CVCL_D3W5 (LNCaP-r)CVCL_WZ25 (LNCaP-SL)
CVCL_E0XF (Ubigene LNCAP Clone FGC BRCA2 KO)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0019003/4953; ATCC=CRL-1740; CCRID=3101HUMSCSP5021; CLS=305220; Cosmic-CLP=907788; ECACC=89110211; KCLB=21740; RCB=RCB2144; TKG=TKG 0603

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133816
D3S135816
D5S81811,12
D7S8209 (RCB=RCB2144)
9,11 (ECACC=89110211; KCLB=21740)
9.1,10.3 (AddexBio=C0019003/4953; ATCC=CRL-1740; CCRID=3101HUMSCSP5021; CLS=305220; TKG=TKG 0603)
11 (Cosmic-CLP=907788)
D8S117912,14
D13S31710,12
D16S53911
D18S5111,12
D19S43313.2,15
D21S1129,32.2
FGA19,20 (ATCC=CRL-1740)
19,20,21 (CLS=305220)
Penta D12,12.4
Penta E12,16
TH019
TPOX8,9
vWA16,17,18 (RCB=RCB2144)
16,18 (AddexBio=C0019003/4953; ATCC=CRL-1740; CCRID=3101HUMSCSP5021; CLS=305220; Cosmic-CLP=907788; ECACC=89110211; KCLB=21740; TKG=TKG 0603)

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/crl-1740-growth-and-morphology
Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/growth-rate-of-atcc-crl-1740
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544554
Publications

PubMed=2734981; DOI=10.1007/BF00262025
Josee J. Konig, Eric Kamst, Anne Hagemeijer, Johannes C. Romijn, Julius Stanislaw Horoszewicz, Fritz H. Schroder;
Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP.
Urol. Res. 17:79-86(1989)

PubMed=8104329; DOI=10.1002/pros.2990230206
Alan G. Carroll, H. James Voeller, LaVencia Sugars, Edward P. Gelmann;
p53 oncogene mutations in three human prostate cancer cell lines.
Prostate 23:123-134(1993)

PubMed=10092147; DOI=10.1007/s002400050082
Josee J. Konig, Wilma J. Teubel, Gert Jan van Steenbrugge, Johannes C. Romijn, Anne Hagemeijer;
Characterization of chromosome 8 aberrations in the prostate cancer cell line LNCaP-FGC and sublines.
Urol. Res. 27:3-8(1999)

PubMed=11172901; DOI=10.1016/S0165-4608(00)00339-3
Jonathan C. Strefford, Debra M. Lillington, Bryan D. Young, R. Timothy D. Oliver;
The use of multicolor fluorescence technologies in the characterization of prostate carcinoma cell lines: a comparison of multiplex fluorescence in situ hybridization and spectral karyotyping data.
Cancer Genet. Cytogenet. 124:112-121(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=15389782; DOI=10.1002/pros.20145
Helene Gustavsson, Karin Welen, Jan-Erik Damber;
Transition of an androgen-dependent human prostate cancer cell line into an androgen-independent subline is associated with increased angiogenesis.
Prostate 62:364-373(2005)

PubMed=15833837; DOI=10.1158/0008-5472.CAN-04-3218
Biao-Yang Lin, James T. White, Wei Lu, Tao Xie, Angelita Gaoiran Utleg, Xiao-Wei Yan, Eugene C. Yi, Paul Shannon, Irina Khrebtukova, Paul Henry Lange, David Robinson Goodlett ...Show all 14 authors... , Dai-Xing Zhou, Thomas Josepth Vasicek, Leroy Edward Hood; Show fewer authors
Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease.
Cancer Res. 65:3081-3091(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23117885; DOI=10.1158/0008-5472.CAN-12-3630; PMCID=PMC3549016
Ying-Ming Li, Siu-Chiu Chan, Lucas J. Brand, Tae Hyun Hwang, Kevin A.T. Silverstein, Scott M. Dehm;
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines.
Cancer Res. 73:483-489(2013)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Katherine E. Varley, Jason Gertz, Kevin M. Bowling, Stephanie L. Parker, Timothy E. Reddy, Florencia Pauli-Behn, Marie K. Cross, Brian A. Williams, John A. Stamatoyannopoulos, Gregory E. Crawford, Devin Michael Absher ...Show all 13 authors... , Barbara Jane Wold, Richard M. Myers; Show fewer authors
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661
Mannan Nouri, Josselin Caradec, Amy Anne Lubik, Na Li, Brett G. Hollier, Mandeep Takhar, Manuel Altimirano-Dimas, Meng-Qian Chen, Mani Roshan-Moniri, Miriam Butler, Melanie Lehman ...Show all 27 authors... , Jennifer L. Bishop, Sarah Truong, Shih-Chieh Huang, Dawn R. Cochrane, Michael Cox, Catherine Collins, Martin E. Gleave, Nicholas Erho, Mohamed Alshalafa, Elai Davicioni, Colleen Nelson, Cheryl Y. Gregory-Evans, R. Jeffrey Karnes, Robert Brian Jenkins, Eric A. Klein, Ralph Buttyan; Show fewer authors
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017)

PubMed=30305041; DOI=10.1186/s12885-018-4848-x; PMCID=PMC6180441
Kasey Jividen, Katarzyna Z. Kedzierska, Chun-Song Yang, Karol Szlachta, Aakrosh Ratan, Bryce M. Paschal;
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.
BMC Cancer 18:960.1-960.20(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) Abcam; ab275470
AddexBio; C0019003/4953
ATCC; CRL-1740
BCRC; 60088
BCRJ; 0149
CLS; 305220
ECACC; 89110211
ICLC; HTL99011
IZSLER; BS TCL 148
KCB; KCB 200732YJ
KCLB; 21740
RCB; RCB2144
TKG; TKG 0603
Ubigene; YC-C009
Cell line databases/resources CLO; CLO_0007366
CLO; CLO_0007367
CLO; CLO_0051537
CLDB; cl3245
CLDB; cl4960
CLDB; cl5222
cancercelllines; CVCL_1379
CCRID; 3101HUMSCSP5021
CCRID; 3101HUMTCHu173
Cell_Model_Passport; SIDM00683
Cosmic-CLP; 907788
DepMap; ACH-000977
Anatomy/cell type resources BTO; BTO_0006095
Biological sample resources 4DN; 4DNSR4OQOB67
BioSample; SAMN03471417
BioSample; SAMN03472018
BioSample; SAMN05292444
BioSample; SAMN10988285
ENCODE; ENCBS089RMT
ENCODE; ENCBS184PDN
ENCODE; ENCBS235TSM
ENCODE; ENCBS260TRO
ENCODE; ENCBS386ENC
ENCODE; ENCBS387ENC
ENCODE; ENCBS418ENC
ENCODE; ENCBS421PUJ
ENCODE; ENCBS422ENC
ENCODE; ENCBS535BWO
ENCODE; ENCBS668DEO
ENCODE; ENCBS680JNS
ENCODE; ENCBS687TQL
ENCODE; ENCBS849SWQ
ENCODE; ENCBS851ZZS
ENCODE; ENCBS918PKZ
CRISP screens repositories BioGRID_ORCS_Cell_line; 930
Chemistry resources ChEMBL-Cells; CHEMBL3308342
ChEMBL-Targets; CHEMBL2366172
GDSC; 907788
PharmacoDB; LNCaPCloneFGC_851_2019
PubChem_Cell_line; CVCL_1379
Encyclopedic resources Wikidata; Q54902825
Experimental variables resources EFO; EFO_0005726
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM383954
GEO; GSM383955
GEO; GSM383956
GEO; GSM651578
GEO; GSM651579
GEO; GSM827569
GEO; GSM887271
GEO; GSM888346
GEO; GSM1633299
GEO; GSM1633300
GEO; GSM1633301
GEO; GSM1633323
GEO; GSM1633324
GEO; GSM1633325
GEO; GSM1670051
GEO; GSM3407130
GEO; GSM3407131
GEO; GSM3407132
GEO; GSM3407133
GEO; GSM3407134
GEO; GSM3407135
Polymorphism and mutation databases Cosmic; 688117
Cosmic; 907788
IARC_TP53; 27698
LiGeA; CCLE_749
Progenetix; CVCL_1379
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number48