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Cellosaurus LNCaP clone FGC (CVCL_1379)

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Cell line name LNCaP clone FGC
Synonyms LNCaP-Clone-FGC; LNCaP.FGC; LNCaP-FGC; LNCaP FGC; LNCAPCLONEFGC; LNCaP-ATCC; LNCaP Fast Growing Colony
Accession CVCL_1379
Resource Identification Initiative To cite this cell line use: LNCaP clone FGC (RRID:CVCL_1379)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Doubling time: 43 hours (PubMed=15389782); ~34 hours (ATCC=CRL-1740); ~36 hours (PBCF); 38.71 hours (JWGray panel).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).
Misspelling: LNCaP.FCG; Note=Occasionally.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (Cosmic-CLP=907788; DepMap=ACH-000977).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (Cosmic-CLP=907788; DepMap=ACH-000977).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (Cosmic-CLP=907788; DepMap=ACH-000977).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (DepMap=ACH-000977).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.89
Native American0.31
East Asian, North0
East Asian, South2.4
South Asian8.61
European, North28.39
European, South57.41
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Children:
CVCL_C0BI (Abcam LNCaP clone FGC TMPRSS2 KO)CVCL_U984 (AILNCaP)CVCL_C0Z9 (JHU-LNCaP-SM)
CVCL_A1BN (LNCaP AR-NTD/pHage)CVCL_A1BM (LNCaP AR-V7/pHage)CVCL_A1BL (LNCaP AR-V7/pLenti)
CVCL_C8W7 (LNCaP Clone FGC-EGFP)CVCL_A4BQ (LNCaP clone FGC-Luc2)CVCL_W668 (LNCaP clone FGC.10)
CVCL_B413 (LNCaP-17)CVCL_WW88 (LNCaP-19)CVCL_B414 (LNCaP-34)
CVCL_ZC87 (LNCaP-95)CVCL_ZX07 (LNCAP-AAR)CVCL_4791 (LNCaP-AI)
CVCL_C7XA (LNCaP-AR)CVCL_5J30 (LNCaP-luc-M6)CVCL_D3W5 (LNCaP-r)
CVCL_WZ25 (LNCaP-SL)CVCL_E0XF (Ubigene LNCAP Clone FGC BRCA2 KO)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0019003/4953; ATCC=CRL-1740; CCRID=3101HUMSCSP5021; CLS=305220; Cosmic-CLP=907788; ECACC=89110211; KCLB=21740; RCB=RCB2144; TKG=TKG 0603

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133816
D3S135816
D5S81811,12
D7S8209.1,10.3 (AddexBio=C0019003/4953; ATCC=CRL-1740; CCRID=3101HUMSCSP5021; CLS=305220; TKG=TKG 0603)
11 (Cosmic-CLP=907788)
9 (RCB=RCB2144)
9,11 (ECACC=89110211; KCLB=21740)
D8S117912,14
D13S31710,12
D16S53911
D18S5111,12
D19S43313.2,15
D21S1129,32.2
FGA19,20 (ATCC=CRL-1740)
19,20,21 (CLS=305220)
Penta D12,12.4
Penta E12,16
TH019
TPOX8,9
vWA16,17,18 (RCB=RCB2144)
16,18 (AddexBio=C0019003/4953; ATCC=CRL-1740; CCRID=3101HUMSCSP5021; CLS=305220; Cosmic-CLP=907788; ECACC=89110211; KCLB=21740; TKG=TKG 0603)

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/growth-rate-of-atcc-crl-1740
https://www.atcc.org/en/support/technical-support/faqs/crl-1740-growth-and-morphology
https://www.synapse.org/#!Synapse:syn31544554
Publications

PubMed=2734981; DOI=10.1007/BF00262025
Konig J.J., Kamst E., Hagemeijer A., Romijn J.C., Horoszewicz J.S., Schroder F.H.
Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP.
Urol. Res. 17:79-86(1989)

PubMed=8104329; DOI=10.1002/pros.2990230206
Carroll A.G., Voeller H.J., Sugars L., Gelmann E.P.
p53 oncogene mutations in three human prostate cancer cell lines.
Prostate 23:123-134(1993)

PubMed=10092147; DOI=10.1007/s002400050082
Konig J.J., Teubel W.J., van Steenbrugge G.J., Romijn J.C., Hagemeijer A.
Characterization of chromosome 8 aberrations in the prostate cancer cell line LNCaP-FGC and sublines.
Urol. Res. 27:3-8(1999)

PubMed=11172901; DOI=10.1016/S0165-4608(00)00339-3
Strefford J.C., Lillington D.M., Young B.D., Oliver R.T.D.
The use of multicolor fluorescence technologies in the characterization of prostate carcinoma cell lines: a comparison of multiplex fluorescence in situ hybridization and spectral karyotyping data.
Cancer Genet. Cytogenet. 124:112-121(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=15389782; DOI=10.1002/pros.20145
Gustavsson H., Welen K., Damber J.-E.
Transition of an androgen-dependent human prostate cancer cell line into an androgen-independent subline is associated with increased angiogenesis.
Prostate 62:364-373(2005)

PubMed=15833837; DOI=10.1158/0008-5472.CAN-04-3218
Lin B.-Y., White J.T., Lu W., Xie T., Utleg A.G., Yan X.-W., Yi E.C., Shannon P., Khrebtukova I., Lange P.H., Goodlett D.R., Zhou D.-X., Vasicek T.J., Hood L.E.
Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease.
Cancer Res. 65:3081-3091(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23117885; DOI=10.1158/0008-5472.CAN-12-3630; PMCID=PMC3549016
Li Y.-M., Chan S.-C., Brand L.J., Hwang T.H., Silverstein K.A.T., Dehm S.M.
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines.
Cancer Res. 73:483-489(2013)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661
Nouri M., Caradec J., Lubik A.A., Li N., Hollier B.G., Takhar M., Altimirano-Dimas M., Chen M.-Q., Roshan-Moniri M., Butler M., Lehman M., Bishop J.L., Truong S., Huang S.-C., Cochrane D.R., Cox M., Collins C., Gleave M.E., Erho N., Alshalafa M., Davicioni E., Nelson C., Gregory-Evans C.Y., Karnes R.J., Jenkins R.B., Klein E.A., Buttyan R.
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017)

PubMed=30305041; DOI=10.1186/s12885-018-4848-x; PMCID=PMC6180441
Jividen K., Kedzierska K.Z., Yang C.-S., Szlachta K., Ratan A., Paschal B.M.
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.
BMC Cancer 18:960.1-960.20(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) Abcam; ab275470
AddexBio; C0019003/4953
ATCC; CRL-1740
BCRC; 60088
BCRJ; 0149
CLS; 305220
ECACC; 89110211
ICLC; HTL99011
IZSLER; BS TCL 148
KCB; KCB 200732YJ
KCLB; 21740
RCB; RCB2144
TKG; TKG 0603
Ubigene; YC-C009
Cell line databases/resources CLO; CLO_0007366
CLO; CLO_0007367
CLO; CLO_0051537
CLDB; cl3245
CLDB; cl4960
CLDB; cl5222
cancercelllines; CVCL_1379
CCRID; 3101HUMSCSP5021
CCRID; 3101HUMTCHu173
Cell_Model_Passport; SIDM00683
Cosmic-CLP; 907788
DepMap; ACH-000977
Anatomy/cell type resources BTO; BTO:0006095
Biological sample resources 4DN; 4DNSR4OQOB67
BioSample; SAMN03471417
BioSample; SAMN03472018
BioSample; SAMN05292444
BioSample; SAMN10988285
ENCODE; ENCBS089RMT
ENCODE; ENCBS184PDN
ENCODE; ENCBS235TSM
ENCODE; ENCBS260TRO
ENCODE; ENCBS386ENC
ENCODE; ENCBS387ENC
ENCODE; ENCBS418ENC
ENCODE; ENCBS421PUJ
ENCODE; ENCBS422ENC
ENCODE; ENCBS535BWO
ENCODE; ENCBS668DEO
ENCODE; ENCBS680JNS
ENCODE; ENCBS687TQL
ENCODE; ENCBS849SWQ
ENCODE; ENCBS851ZZS
ENCODE; ENCBS918PKZ
CRISP screens repositories BioGRID_ORCS_Cell_line; 930
Chemistry resources ChEMBL-Cells; CHEMBL3308342
ChEMBL-Targets; CHEMBL2366172
GDSC; 907788
PharmacoDB; LNCaPCloneFGC_851_2019
PubChem_Cell_line; CVCL_1379
Encyclopedic resources Wikidata; Q54902825
Experimental variables resources EFO; EFO_0005726
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM383954
GEO; GSM383955
GEO; GSM383956
GEO; GSM651578
GEO; GSM651579
GEO; GSM827569
GEO; GSM887271
GEO; GSM888346
GEO; GSM1633299
GEO; GSM1633300
GEO; GSM1633301
GEO; GSM1633323
GEO; GSM1633324
GEO; GSM1633325
GEO; GSM1670051
GEO; GSM3407130
GEO; GSM3407131
GEO; GSM3407132
GEO; GSM3407133
GEO; GSM3407134
GEO; GSM3407135
Polymorphism and mutation databases Cosmic; 688117
Cosmic; 907788
IARC_TP53; 27698
LiGeA; CCLE_749
Progenetix; CVCL_1379
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number46