| Cell line name |
LNCaP-SL |
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| Synonyms |
Stem-Like LNCaP; LNCaP-Stem Like |
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| Accession |
CVCL_WZ25 |
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| Resource Identification Initiative |
To cite this cell line use: LNCaP-SL (RRID:CVCL_WZ25) |
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| Comments |
Population: Caucasian.
Characteristics: Reprogrammed to, maintained and propagated as cancer stem-like cells (CSCs) by growth in androgen-free neural/neural crest (N/NC) stem medium.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1379 (LNCaP clone FGC) |
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| Sex of cell |
Male |
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| Age at sampling |
50Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661
Mannan Nouri, Josselin Caradec, Amy Anne Lubik, Na Li, Brett G. Hollier, Mandeep Takhar, Manuel Altimirano-Dimas, Meng-Qian Chen, Mani Roshan-Moniri, Miriam Butler, Melanie Lehman ...Show all 27 authors... , Jennifer L. Bishop, Sarah Truong, Shih-Chieh Huang, Dawn R. Cochrane, Michael Cox, Catherine Collins, Martin E. Gleave, Nicholas Erho, Mohamed Alshalafa, Elai Davicioni, Colleen Nelson, Cheryl Y. Gregory-Evans, R. Jeffrey Karnes, Robert Brian Jenkins, Eric A. Klein, Ralph Buttyan; Show fewer authors
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_WZ25
|
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| Encyclopedic resources |
Wikidata; Q95982793
|
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| Gene expression databases |
GEO; GSM1633302
GEO; GSM1633303
GEO; GSM1633304
|
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| Entry history |
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| Entry creation | 06-Sep-2019 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 10 |
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