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Cellosaurus LNCaP-AI (CVCL_4791)

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Cell line name LNCaP-AI
Synonyms LNCAPAI; LNCaP-Androgen-Independent
Accession CVCL_4791
Resource Identification Initiative To cite this cell line use: LNCaP-AI (RRID:CVCL_4791)
Comments Population: Caucasian.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=10537131; DOI=10.1210/endo.140.11.7086
Shan Lu, Sophia Y. Tsai, Ming-Jer Tsai;
Molecular mechanisms of androgen-independent growth of human prostate cancer LNCaP-AI cells.
Endocrinology 140:5054-5059(1999)

PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065; PMCID=PMC9153264
Cory Abate-Shen, Francisca Nunes de Almeida;
Establishment of the LNCaP cell line -- the dawn of an era for prostate cancer research.
Cancer Res. 82:1689-1691(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4791
Encyclopedic resources Wikidata; Q54902831
Gene expression databases GEO; GSM1374623
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number23