ID   LNCaP-AI
AC   CVCL_4791
SY   LNCAPAI; LNCaP-Androgen-Independent
DR   cancercelllines; CVCL_4791
DR   GEO; GSM1374623
DR   Wikidata; Q54902831
RX   PubMed=10537131;
RX   PubMed=35502546;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1379 ! LNCaP clone FGC
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
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RX   PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065; PMCID=PMC9153264;
RA   Abate-Shen, Cory
RA   Nunes de Almeida, Francisca
RT   "Establishment of the LNCaP cell line -- the dawn of an era for
RT   prostate cancer research.";
RL   Cancer Res. 82:1689-1691(2022).
//
RX   PubMed=10537131; DOI=10.1210/endo.140.11.7086;
RA   Lu, Shan
RA   Tsai, Sophia Y.
RA   Tsai, Ming-Jer
RT   "Molecular mechanisms of androgen-independent growth of human prostate
RT   cancer LNCaP-AI cells.";
RL   Endocrinology 140:5054-5059(1999).
//