| Cell line name |
AILNCaP |
|---|
| Synonyms |
AI LNCaP; AI-LNCaP; Androgen-Independent LNCaP |
|---|
| Accession |
CVCL_U984 |
|---|
| Resource Identification Initiative |
To cite this cell line use: AILNCaP (RRID:CVCL_U984) |
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| Comments |
Population: Caucasian.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_1379 (LNCaP clone FGC) |
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| Sex of cell |
Male |
|---|
| Age at sampling |
50Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=16931574; DOI=10.1210/me.2006-0033
Takahiro Inoue, Toru Yoshida, Yosuke Shimizu, Takashi Kobayashi, Toshinari Yamasaki, Yoshinobu Toda, Takehiko Segawa, Toshiyuki Kamoto, Eijiro Nakamura, Osamu Ogawa;
Requirement of androgen-dependent activation of protein kinase Czeta for androgen-dependent cell proliferation in LNCaP Cells and its roles in transition to androgen-independent cells.
Mol. Endocrinol. 20:3053-3069(2006) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_U984
|
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| Anatomy/cell type resources |
BTO; BTO_0004799
|
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| Encyclopedic resources |
Wikidata; Q54748998
|
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| Entry history |
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| Entry creation | 16-Apr-2014 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 17 |
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