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Cellosaurus JHU-LNCaP-SM (CVCL_C0Z9)

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Cell line name JHU-LNCaP-SM
Accession CVCL_C0Z9
Resource Identification Initiative To cite this cell line use: JHU-LNCaP-SM (RRID:CVCL_C0Z9)
Comments Population: Caucasian.
Characteristics: Androgen-independent. Forms subcutaneous tumors in male athymic nude mice and reliably metastasize to the lymph nodes (PubMed=26499105).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (PubMed=26499105).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): PubMed=26499105

Markers:
AmelogeninX
CSF1PO9,10,11,12
D5S81810,11,12,13
D7S8209.1,10.1,10.2,10.3
D13S3179,11,12,13
D16S53910,11
TH019
TPOX9
vWA15,16,17,18

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Publications

PubMed=26499105; DOI=10.1002/pros.23115; PMCID=PMC4729204
Mark A. Castanares, Ben T. Copeland, Wasim H. Chowdhury, Minzhi M. Liu, Ronald Rodriguez, Martin G. Pomper, Shawn E. Lupold, Catherine A. Foss;
Characterization of a novel metastatic prostate cancer cell line of LNCaP origin.
Prostate 76:215-225(2016)

PubMed=36261691; DOI=10.1038/s41598-022-21593-7; PMCID=PMC9582213
Nawel Mekdad, Thi Minh Hue Tran, Roxane Desjardins, Anna Kwiatkowska, Frederic Couture, Robert Day;
Efficacy of PACE4 pharmacotherapy in JHU-LNCaP-SM preclinical model of androgen independent prostate cancer.
Sci. Rep. 12:17489.1-17489.12(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0Z9
Encyclopedic resources Wikidata; Q114311775
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6