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Cellosaurus LNCaP AR-NTD/pHage (CVCL_A1BN)

[Text version]
Cell line name LNCaP AR-NTD/pHage
Synonyms LNCaPAR-NTD/pHage
Accession CVCL_A1BN
Resource Identification Initiative To cite this cell line use: LNCaP AR-NTD/pHage (RRID:CVCL_A1BN)
Comments Population: Caucasian.
Characteristics: Inducibly expresses AR N-terminal domain (AR-NTD).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:644; AR (Note=With p.Thr661_Gln920del = AR-NTD).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=25008967; DOI=10.1016/j.biocel.2014.06.013; PMCID=PMC4160387
Krause W.C., Shafi A.A., Nakka M., Weigel N.L.
Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells.
Int. J. Biochem. Cell Biol. 54:49-59(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1BN
Encyclopedic resources Wikidata; Q102114469
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number9