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Cellosaurus LNCaP-AR (CVCL_C7XA)

[Text version]
Cell line name LNCaP-AR
Accession CVCL_C7XA
Resource Identification Initiative To cite this cell line use: LNCaP-AR (RRID:CVCL_C7XA)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:644; AR.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=14702632; DOI=10.1038/nm972
Charlie D. Chen, Derek S. Welsbie, Chris Tran, Sung Hee Baek, Randy Chen, Robert Louis Vessella, Michael Geoffrey Rosenfeld, Charles Lazelle Sawyers;
Molecular determinants of resistance to antiandrogen therapy.
Nat. Med. 10:33-39(2004)

PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065; PMCID=PMC9153264
Cory Abate-Shen, Francisca Nunes de Almeida;
Establishment of the LNCaP cell line -- the dawn of an era for prostate cancer research.
Cancer Res. 82:1689-1691(2022)

Cross-references
Encyclopedic resources Wikidata; Q123032971
Entry history
Entry creation29-Jun-2023
Last entry update14-Aug-2025
Version number6