ID   LNCaP-AR
AC   CVCL_C7XA
DR   Wikidata; Q123032971
RX   PubMed=14702632;
RX   PubMed=35502546;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:644; AR.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1379 ! LNCaP clone FGC
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 29-06-23; Last updated: 14-08-25; Version: 6
//
RX   PubMed=14702632; DOI=10.1038/nm972;
RA   Chen, Charlie D.
RA   Welsbie, Derek S.
RA   Tran, Chris
RA   Baek, Sung Hee
RA   Chen, Randy
RA   Vessella, Robert Louis
RA   Rosenfeld, Michael Geoffrey
RA   Sawyers, Charles Lazelle
RT   "Molecular determinants of resistance to antiandrogen therapy.";
RL   Nat. Med. 10:33-39(2004).
//
RX   PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065; PMCID=PMC9153264;
RA   Abate-Shen, Cory
RA   Nunes de Almeida, Francisca
RT   "Establishment of the LNCaP cell line -- the dawn of an era for
RT   prostate cancer research.";
RL   Cancer Res. 82:1689-1691(2022).
//