Cell line name |
LNCaP-r |
Accession |
CVCL_D3W5 |
Resource Identification Initiative |
To cite this cell line use: LNCaP-r (RRID:CVCL_D3W5) |
Comments |
Population: Caucasian. Characteristics: Resistant to androgen (PubMed=4048015). Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
Disease |
Prostate carcinoma (NCIt: C4863) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_1379 (LNCaP clone FGC) |
Sex of cell |
Male |
Age at sampling |
50Y |
Category |
Cancer cell line |
Publications | PubMed=4048015; DOI=10.1002/pros.2990070208 Michael Hasenson, Beryl Hartley-Asp, Christer Kihlfors, Arne Lundin, Jan-Ake Gustafsson, Ake Pousette; Effect of hormones on growth and ATP content of a human prostatic carcinoma cell line, LNCaP-r. Prostate 7:183-194(1985) PubMed=2734981; DOI=10.1007/BF00262025 Josee J. Konig, Eric Kamst, Anne Hagemeijer, Johannes C. Romijn, Julius Stanislaw Horoszewicz, Fritz H. Schroder; Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP. Urol. Res. 17:79-86(1989) PubMed=10092147; DOI=10.1007/s002400050082 Josee J. Konig, Wilma J. Teubel, Gert Jan van Steenbrugge, Johannes C. Romijn, Anne Hagemeijer; Characterization of chromosome 8 aberrations in the prostate cancer cell line LNCaP-FGC and sublines. Urol. Res. 27:3-8(1999) |
Cross-references |
Encyclopedic resources |
Wikidata; Q127382614
|
Entry history |
Entry creation | 30-Jan-2024 |
Last entry update | 19-Dec-2024 |
Version number | 3 |
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