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Cellosaurus LNCaP-r (CVCL_D3W5)

[Text version]
Cell line name LNCaP-r
Accession CVCL_D3W5
Resource Identification Initiative To cite this cell line use: LNCaP-r (RRID:CVCL_D3W5)
Comments Population: Caucasian.
Characteristics: Resistant to androgen (PubMed=4048015).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=4048015; DOI=10.1002/pros.2990070208
Michael Hasenson, Beryl Hartley-Asp, Christer Kihlfors, Arne Lundin, Jan-Ake Gustafsson, Ake Pousette;
Effect of hormones on growth and ATP content of a human prostatic carcinoma cell line, LNCaP-r.
Prostate 7:183-194(1985)

PubMed=2734981; DOI=10.1007/BF00262025
Josee J. Konig, Eric Kamst, Anne Hagemeijer, Johannes C. Romijn, Julius Stanislaw Horoszewicz, Fritz H. Schroder;
Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP.
Urol. Res. 17:79-86(1989)

PubMed=10092147; DOI=10.1007/s002400050082
Josee J. Konig, Wilma J. Teubel, Gert Jan van Steenbrugge, Johannes C. Romijn, Anne Hagemeijer;
Characterization of chromosome 8 aberrations in the prostate cancer cell line LNCaP-FGC and sublines.
Urol. Res. 27:3-8(1999)

Cross-references
Encyclopedic resources Wikidata; Q127382614
Entry history
Entry creation30-Jan-2024
Last entry update19-Dec-2024
Version number3