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Cellosaurus MKN45 (CVCL_0434)

[Text version]
Cell line name MKN45
Synonyms MKN-45; MKN 45
Accession CVCL_0434
Resource Identification Initiative To cite this cell line use: MKN45 (RRID:CVCL_0434)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: JFCR39 cancer cell line panel.
Part of: JFCR45 cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Characteristics: MET-amplified, contains 12-13 copies of the gene (PubMed=29435981).
Doubling time: 30-33 hours (PubMed=3962675); 33 hours (PubMed=29435981); 30-38 hours (CelloPub=CLPUB00584); 16 hours (PubMed=2105279); ~60 hours (DSMZ=ACC-409).
Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Caution: Was indicated not to have a TP53 mutation in PubMed=1370612 and PubMed=15900046.
Misspelling: MKN46; Cosmic=968349.
Misspelling: MNK-45; Note=Occasionally.
Misspelling: MNK45; Note=Occasionally.
Misspelling: NKM-45; Note=Occasionally.
Misspelling: NKM45; Note=Occasionally.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (Cosmic-CLP=925340; DepMap=ACH-000356).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01
HLA-CC*12:02,12:02

Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01,67:02
HLA-CC*12:02,12:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.54
Native American0
East Asian, North85.37
East Asian, South9.42
South Asian0
European, North0
European, South3.67
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_7668 (GTL-16)CVCL_E1M7 (HyCyte MKN45 KO-hSORCS2)CVCL_E3I1 (HyCyte MKN45-Luc)
CVCL_XE84 (MKN45-Cas9-526)CVCL_UW57 (MKN45-EGFP)CVCL_J262 (MKN45-Luc)
CVCL_YX96 (MKN45/CDDP/R1)CVCL_E2W7 (MKN45/CV)CVCL_A9J7 (MKN45/DR)
CVCL_QY39 (MKN45/F2R)CVCL_9645 (MKN45/TP)CVCL_D5HU (MKN45cl85)
CVCL_RM02 (MKN45G)CVCL_Y476 (MKN45P)CVCL_Z941 (MKN45R0.05)
CVCL_Z942 (MKN45R0.08)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000229; CLS=300489; Cosmic-CLP=925340; DSMZ=ACC-409; JCRB=JCRB0254; KCLB=80103; PubMed=25877200; RCB=RCB1001

Markers:
AmelogeninX
CSF1PO12
D2S133818
D3S135815,16
D5S81810,11
D6S104314
D7S82010,11
D8S117913,17
D12S39126
D13S3178,11
D16S53910
D18S5116
D19S43314,16.2 (CCRID=1101HUM-PUMC000229; CLS=300489)
14,17 (DSMZ=ACC-409)
D21S1131
FGA19 (KCLB=80103)
19,24 (CCRID=1101HUM-PUMC000229; CLS=300489; DSMZ=ACC-409; PubMed=25877200)
Penta D10
Penta E10
TH017
TPOX8
vWA19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-496.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/gastric-xenograft-model/mkn-45-xenograft-model/
Publications

CLPUB00581
Haruto Hojo;
Establishment of cultured cell lines of human stomach cancer origin and their morphological characteristics.
Niigata Igakkai Zasshi 91:737-763(1977)

CLPUB00584
Teiichi Motoyama, Haruto Hojo, Toshimitsu Suzuki, Shoichi Oboshi;
Evaluation of the regrowth assay method as an in vitro drug sensitivity test and its application to cultured human gastric cancer cell lines.
Acta Med. Biol. 27:49-63(1979)

PubMed=758928; DOI=10.1038/bjc.1979.3; PMCID=PMC2009802
Mitsuru Kinjo, Kazunari Oka, S. Naito, Shin Kohga, Kenzo Tanaka, Shoichi Oboshi, Yoshihiro Hayata, Kosei Yasumoto;
Thromboplastic and fibrinolytic activities of cultured human cancer cell lines.
Br. J. Cancer 39:15-23(1979)

PubMed=6862145; DOI=10.20772/cancersci1959.74.2_240
Seiji Naito, Sadami Inoue, Mitsuru Kinjo, Kenzo Tanaka;
Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines.
Gann 74:240-247(1983)

PubMed=3986962; DOI=10.1093/carcin/6.4.549
Masahiro Watatani, Mituo Ikenaga, Toshihiro Hatanaka, Masakatsu Kinuta, Shin-ichiro Takai, Takesada Mori, Sohei Kondo;
Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.
Carcinogenesis 6:549-553(1985)

PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x
Teiichi Motoyama, Haruto Hojo, Hidenobu Watanabe;
Comparison of seven cell lines derived from human gastric carcinomas.
Acta Pathol. Jpn. 36:65-83(1986)

PubMed=2105279; DOI=10.1002/ijc.2910450117
Susan A. Watson, Lindy G. Durrant, David Lawson Morris;
The effect of the E2 prostaglandin enprostil, and the somatostatin analogue SMS 201 995, on the growth of a human gastric cell line, MKN45G.
Int. J. Cancer 45:90-94(1990)

PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361
Eisuke Takeshima, Michinari Hamaguchi, Tadashi Watanabe, Seiji Akiyama, Masato Kataoka, Yukano Ohnishi, Heng-Yi Xiao, Yoshiyuki Nagai, Hiroshi Takagi;
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Jpn. J. Cancer Res. 82:1428-1435(1991)

PubMed=1846553; DOI=10.1038/bjc.1991.14; PMCID=PMC1971664
Lindy G. Durrant, Susan A. Watson, A. Hall, David Lawson Morris;
Co-stimulation of gastrointestinal tumour cell growth by gastrin, transforming growth factor alpha and insulin like growth factor-I.
Br. J. Cancer 63:67-70(1991)

PubMed=1933850
Yukishige Yamada, Teruhiko Yoshida, Kenshi Hayashi, Takao Sekiya, Jun Yokota, Setsuo Hirohashi, Katsunori Nakatani, Hiroshige Nakano, Takashi Sugimura, Masaaki Terada;
p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.
Cancer Res. 51:5800-5805(1991)

PubMed=2061947; DOI=10.1093/jnci/83.12.866
Susan A. Watson, Lindy G. Durrant, Pete M. Wencyk, A.L. Watson, David Lawson Morris;
Intracellular gastrin in human gastrointestinal tumor cells.
J. Natl. Cancer Inst. 83:866-871(1991)

PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0
Takashi Matozaki, Choitsu Sakamoto, Kohei Matsuda, Toshiya Suzuki, Yoshitaka Konda, Osamu Nakano, Ken Wada, Tohru Uchida, Hogara Nishisaki, Munehiko Nagao, Masato Kasuga;
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Biochem. Biophys. Res. Commun. 182:215-223(1992)

PubMed=1486568; DOI=10.1016/0165-4608(92)90350-H
Giovanna Rege-Cambrin, Patrizia Scaravaglio, Franca Carozzi, Silvia Giordano, Carola Ponzetto, Paolo Maria Comoglio, Giuseppe Saglio;
Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.
Cancer Genet. Cytogenet. 64:170-173(1992)

DOI=10.1016/B978-0-12-333530-2.50014-9
Morimasa Sekiguchi, Toshimitsu Suzuki;
Gastric tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.287-316; Academic Press; New York; USA (1994)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9247707; DOI=10.1080/15216549700202901
Setsuko Hatakeyama, Yu-Hao Gao, Yuko Ohara-Nemoto, Hiroaki Kataoka, Masanobu Satoh;
Expression of bone morphogenetic proteins of human neoplastic epithelial cells.
Biochem. Mol. Biol. Int. 42:497-505(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9665481; DOI=10.1016/S0002-9440(10)65561-7; PMCID=PMC1852940
Rosanna Paciucci, Maya R. Vila, Teresa Adell, Victor M. Diaz, Montserrat Tora, Toshikazu Nakamura, Francisco X. Real;
Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.
Am. J. Pathol. 153:201-212(1998)

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x
Hiroshi Yokozaki;
Molecular characteristics of eight gastric cancer cell lines established in Japan.
Pathol. Int. 50:767-777(2000)

PubMed=11314020; DOI=10.1038/sj.onc.1204160
Hiromi Kataoka, Yutaka Miura, Takashi Joh, Kyoji Seno, Toyohiro Tada, Taiki Tamaoki, Hidekazu Nakabayashi, Makoto Kawaguchi, Kiyofumi Asai, Taiji Kato, Makoto Itoh;
Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1.
Oncogene 20:869-873(2001)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020
Hisashi Takada, Issei Imoto, Hitoshi Tsuda, Itaru Sonoda, Takashi Ichikura, Hidetaka Mochizuki, Takeshi Okanoue, Johji Inazawa;
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Noriyuki Nakatsu, Yoko Yoshida, Kanami Yamazaki, Tomoki Nakamura, Shingo Dan, Yasuhisa Fukui, Takao Yamori;
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=15900046; DOI=10.1093/jnci/dji133
Tetsuo Mashima, Tomoko Oh-hara, Shigeo Sato, Mikiko Mochizuki, Yoshikazu Sugimoto, Kanami Yamazaki, Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Yuichi Ishikawa, Yo Kato ...Show all 14 authors... , Hiroshi Tomoda, Takao Yamori, Takashi Tsuruo; Show fewer authors
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
J. Natl. Cancer Inst. 97:765-777(2005)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Yoshihiro Murai, Shinichi Hayashi, Hiroyuki Takahashi, Koichi Tsuneyama, Yasuo Takano;
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

PubMed=18804159; DOI=10.1016/j.ygeno.2008.08.002
Jae-Joon Jung, Hei-Cheul Jeung, Hyun Cheol Chung, Jung Ok Lee, Tae Soo Kim, Yong Tai Kim, Sung Hoon Noh, Sun Young Rha;
In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.
Genomics 93:52-61(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22531121; DOI=10.2739/kurumemedj.58.73
Atsuhiko Koga, Keishiro Aoyagi, Takuya Imaizumi, Motoshi Miyagi, Kazuo Shirouzu;
Comparison between the gastric cancer cell line MKN-45 and the high-potential peritoneal dissemination gastric cancer cell line MKN-45P.
Kurume Med. J. 58:73-79(2011)

PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017
De-Xin Kong, Takao Yamori;
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Bioorg. Med. Chem. 20:1947-1951(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

PubMed=24587255; DOI=10.1371/journal.pone.0090155; PMCID=PMC3937424
Fumitaka Endo, Satoshi S. Nishizuka, Kohei Kume, Kazushige Ishida, Hirokatsu Katagiri, Kaoru Ishida, Kei Sato, Takeshi Iwaya, Keisuke Koeda, Go Wakabayashi;
A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.
PLoS ONE 9:e90155.1-e90155.8(2014)

PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760
Jin-Feng Liu, Mark L. McCleland, Eric W. Stawiski, Florian Gnad, Oleg Mayba, Peter M. Haverty, Steffen Durinck, Ying-Jiun Chen, Christiaan Klijn, Suchit Jhunjhunwala, Michael Lawrence ...Show all 30 authors... , Han-Bin Liu, Yi-Nan Wan, Vivek S. Chopra, Murat Burat Yaylaoglu, Wen-Lin Yuan, Connie Ha, Houston N. Gilbert, Jens Reeder, Gregoire Pau, Jeremy Stinson, Howard M. Stern, Gerard Manning, Thomas D. Wu, Richard M. Neve, Frederic J. de Sauvage, Zora Modrusan, Somasekar Seshagiri, Ron Firestein, Ze-Min Zhang; Show fewer authors
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830.1-3830.8(2014)

PubMed=25343454; DOI=10.1371/journal.pone.0111146; PMCID=PMC4208810
Meng-Ling Choong, Shan-Ho Tan, Tuan-Zea Tan, Sravanthy Manesh, Anna Ngo, Jacklyn W.-Y. Yong, Henry He Yang, May Ann Lee;
Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.
PLoS ONE 9:e111146.1-e111146.9(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29435981; DOI=10.1002/ijc.31304
Hyun Jeong Kim, Sun Kyoung Kang, Woo Sun Kwon, Tae Soo Kim, Inhye Jeong, Hei-Cheul Jeung, Michael Kragh, Ivan D. Horak, Hyun Cheol Chung, Sun Young Rha;
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
Int. J. Cancer 143:151-159(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

DOI=10.1016/j.procbio.2020.01.033
Farhad Pouremamali, Farhad Jeddi, Nasser Samadi;
Nrf2-ME-1 axis is associated with 5-FU resistance in gastric cancer cell line.
Process Biochem. 114:174-184(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CCTCC; GDC0220
CLS; 300489
DSMZ; ACC-409
IBRC; C10137
JCRB; JCRB0254
KCLB; 80103
NCBI_Iran; C615
RCB; RCB1001
Cell line databases/resources CLO; CLO_0007733
CLO; CLO_0050797
MCCL; MCC:0000329
cancercelllines; CVCL_0434
CCRID; 1101HUM-PUMC000229
Cell_Model_Passport; SIDM00247
CGH-DB; 120-1
CGH-DB; 9022-4
Cosmic-CLP; 925340
DepMap; ACH-000356
DSMZCellDive; ACC-409
LINCS_LDP; LCL-1535
Anatomy/cell type resources BTO; BTO_0001225
Biological sample resources BioSample; SAMN03473237
BioSample; SAMN03473585
BioSample; SAMN10988555
CRISP screens repositories BioGRID_ORCS_Cell_line; 404
Chemistry resources ChEMBL-Cells; CHEMBL3307603
ChEMBL-Targets; CHEMBL614354
GDSC; 925340
PharmacoDB; MKN45_938_2019
PubChem_Cell_line; CVCL_0434
Encyclopedic resources Wikidata; Q28473066
Experimental variables resources EFO; EFO_0002832
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10612-108F9
GEO; GSM552364
GEO; GSM562395
GEO; GSM618013
GEO; GSM618014
GEO; GSM618015
GEO; GSM618016
GEO; GSM827532
GEO; GSM828836
GEO; GSM844607
GEO; GSM887324
GEO; GSM888400
GEO; GSM1374681
GEO; GSM1670113
Polymorphism and mutation databases Cosmic; 685596
Cosmic; 801339
Cosmic; 848147
Cosmic; 848373
Cosmic; 873711
Cosmic; 877042
Cosmic; 887256
Cosmic; 888827
Cosmic; 897535
Cosmic; 918497
Cosmic; 922696
Cosmic; 925340
Cosmic; 926114
Cosmic; 968349
Cosmic; 983727
Cosmic; 1001651
Cosmic; 1001655
Cosmic; 1007602
Cosmic; 1090461
Cosmic; 1093299
Cosmic; 1187283
Cosmic; 1223589
Cosmic; 1329185
Cosmic; 1436026
Cosmic; 1460707
Cosmic; 1518241
Cosmic; 1518255
Cosmic; 1582430
Cosmic; 1627265
Cosmic; 1995510
Cosmic; 2036663
Cosmic; 2807633
Cosmic; 2823225
IARC_TP53; 21633
IARC_TP53; 30213
LiGeA; CCLE_725
Progenetix; CVCL_0434
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number49