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Cellosaurus GTL-16 (CVCL_7668)

[Text version]
Cell line name GTL-16
Synonyms GTL 16; GTL16
Accession CVCL_7668
Resource Identification Initiative To cite this cell line use: GTL-16 (RRID:CVCL_7668)
Comments Population: Japanese.
Characteristics: MET is amplified and overexpressed in this cell line.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01,67:02
HLA-CC*12:02,12:02
Class II
HLA-DRDRB1*14:01,14:01
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0434 (MKN45)
Children:
CVCL_VS67 (GTL16R1)CVCL_VS68 (GTL16R3)CVCL_VS69 (GTL16S5)
CVCL_7696 (PR-GTL-16)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=2541345; DOI=10.1038/339155a0
Silvia Giordano, Carola Ponzetto, Maria Flavia Di Renzo, Colin S. Cooper, Paolo Maria Comoglio;
Tyrosine kinase receptor indistinguishable from the c-met protein.
Nature 339:155-156(1989)

PubMed=1674365
Carola Ponzetto, Silvia Giordano, Fiorenzo Peverali, Giuliano Della Valle, Marial Lorena Abate, Giovanna Vaula, Paolo Maria Comoglio;
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase.
Oncogene 6:553-559(1991)

PubMed=1486568; DOI=10.1016/0165-4608(92)90350-H
Giovanna Rege-Cambrin, Patrizia Scaravaglio, Franca Carozzi, Silvia Giordano, Carola Ponzetto, Paolo Maria Comoglio, Giuseppe Saglio;
Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.
Cancer Genet. Cytogenet. 64:170-173(1992)

PubMed=22745804; DOI=10.1371/journal.pone.0039653; PMCID=PMC3382171
Nathan V. Lee, Maruja E. Lira, Adam Pavlicek, Jing-Jing Ye, Dana Buckman, Shubha Bagrodia, Sreesha P. Srinivasa, Yong-Jun Zhao, Samuel Aparicio, Paul A. Rejto, James Gail Christensen, Keith A. Ching;
A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through MAPK activation.
PLoS ONE 7:e39653.1-e39653.12(2012)

PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760
Jin-Feng Liu, Mark L. McCleland, Eric W. Stawiski, Florian Gnad, Oleg Mayba, Peter M. Haverty, Steffen Durinck, Ying-Jiun Chen, Christiaan Klijn, Suchit Jhunjhunwala, Michael Lawrence ...Show all 30 authors... , Han-Bin Liu, Yi-Nan Wan, Vivek S. Chopra, Murat Burat Yaylaoglu, Wen-Lin Yuan, Connie Ha, Houston N. Gilbert, Jens Reeder, Gregoire Pau, Jeremy Stinson, Howard M. Stern, Gerard Manning, Thomas D. Wu, Richard M. Neve, Frederic J. de Sauvage, Zora Modrusan, Somasekar Seshagiri, Ron Firestein, Ze-Min Zhang; Show fewer authors
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830.1-3830.8(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7668
Chemistry resources ChEMBL-Cells; CHEMBL3308698
ChEMBL-Targets; CHEMBL612708
PharmacoDB; GTL16_418_2019
PubChem_Cell_line; CVCL_7668
Encyclopedic resources Wikidata; Q54871835
Experimental variables resources EFO; EFO_0006578
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM685812
GEO; GSM686033
GEO; GSM686034
GEO; GSM843505
GEO; GSM1178098
GEO; GSM1178099
GEO; GSM1374485
GEO; GSM1374486
Polymorphism and mutation databases Cosmic; 755306
Cosmic; 755613
Cosmic; 887246
Cosmic; 1945868
Cosmic; 2069777
Cosmic; 2484973
Cosmic; 2807624
Progenetix; CVCL_7668
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31