ID   GTL-16
AC   CVCL_7668
SY   GTL 16; GTL16
DR   EFO; EFO_0006578
DR   ArrayExpress; E-MTAB-2706
DR   cancercelllines; CVCL_7668
DR   ChEMBL-Cells; CHEMBL3308698
DR   ChEMBL-Targets; CHEMBL612708
DR   Cosmic; 755306
DR   Cosmic; 755613
DR   Cosmic; 887246
DR   Cosmic; 1945868
DR   Cosmic; 2069777
DR   Cosmic; 2484973
DR   Cosmic; 2807624
DR   EGA; EGAS00001000610
DR   GEO; GSM685812
DR   GEO; GSM686033
DR   GEO; GSM686034
DR   GEO; GSM843505
DR   GEO; GSM1178098
DR   GEO; GSM1178099
DR   GEO; GSM1374485
DR   GEO; GSM1374486
DR   PharmacoDB; GTL16_418_2019
DR   Progenetix; CVCL_7668
DR   PubChem_Cell_line; CVCL_7668
DR   Wikidata; Q54871835
RX   PubMed=1486568;
RX   PubMed=1674365;
RX   PubMed=2541345;
RX   PubMed=22745804;
RX   PubMed=24807215;
RX   PubMed=25485619;
RX   PubMed=26589293;
CC   Population: Japanese.
CC   Characteristics: MET is amplified and overexpressed in this cell line.
CC   HLA typing: A*24:02,24:02; B*52:01,67:02; C*12:02,12:02; DRB1*14:01,14:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0434 ! MKN45
SX   Female
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
CH   CVCL_VS67 ! GTL16R1
CH   CVCL_VS68 ! GTL16R3
CH   CVCL_VS69 ! GTL16S5
CH   CVCL_7696 ! PR-GTL-16
//
RX   PubMed=2541345; DOI=10.1038/339155a0;
RA   Giordano, Silvia
RA   Ponzetto, Carola
RA   Di Renzo, Maria Flavia
RA   Cooper, Colin S.
RA   Comoglio, Paolo Maria
RT   "Tyrosine kinase receptor indistinguishable from the c-met protein.";
RL   Nature 339:155-156(1989).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760;
RA   Liu, Jin-Feng
RA   McCleland, Mark L.
RA   Stawiski, Eric W.
RA   Gnad, Florian
RA   Mayba, Oleg
RA   Haverty, Peter M.
RA   Durinck, Steffen
RA   Chen, Ying-Jiun
RA   Klijn, Christiaan
RA   Jhunjhunwala, Suchit
RA   Lawrence, Michael
RA   Liu, Han-Bin
RA   Wan, Yi-Nan
RA   Chopra, Vivek S.
RA   Yaylaoglu, Murat Burat
RA   Yuan, Wen-Lin
RA   Ha, Connie
RA   Gilbert, Houston N.
RA   Reeder, Jens
RA   Pau, Gregoire
RA   Stinson, Jeremy
RA   Stern, Howard M.
RA   Manning, Gerard
RA   Wu, Thomas D.
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Modrusan, Zora
RA   Seshagiri, Somasekar
RA   Firestein, Ron
RA   Zhang, Ze-Min
RT   "Integrated exome and transcriptome sequencing reveals ZAK isoform
RT   usage in gastric cancer.";
RL   Nat. Commun. 5:3830.1-3830.8(2014).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=1674365;
RA   Ponzetto, Carola
RA   Giordano, Silvia
RA   Peverali, Fiorenzo
RA   Della Valle, Giuliano
RA   Abate, Marial Lorena
RA   Vaula, Giovanna
RA   Comoglio, Paolo Maria
RT   "c-met is amplified but not mutated in a cell line with an activated
RT   met tyrosine kinase.";
RL   Oncogene 6:553-559(1991).
//
RX   PubMed=22745804; DOI=10.1371/journal.pone.0039653; PMCID=PMC3382171;
RA   Lee, Nathan V.
RA   Lira, Maruja E.
RA   Pavlicek, Adam
RA   Ye, Jing-Jing
RA   Buckman, Dana
RA   Bagrodia, Shubha
RA   Srinivasa, Sreesha P.
RA   Zhao, Yong-Jun
RA   Aparicio, Samuel
RA   Rejto, Paul A.
RA   Christensen, James Gail
RA   Ching, Keith A.
RT   "A novel SND1-BRAF fusion confers resistance to c-Met inhibitor
RT   PF-04217903 in GTL16 cells through MAPK activation.";
RL   PLoS ONE 7:e39653.1-e39653.12(2012).
//
RX   PubMed=1486568; DOI=10.1016/0165-4608(92)90350-H;
RA   Rege-Cambrin, Giovanna
RA   Scaravaglio, Patrizia
RA   Carozzi, Franca
RA   Giordano, Silvia
RA   Ponzetto, Carola
RA   Comoglio, Paolo Maria
RA   Saglio, Giuseppe
RT   "Karyotypic analysis of gastric carcinoma cell lines carrying an
RT   amplified c-met oncogene.";
RL   Cancer Genet. Cytogenet. 64:170-173(1992).
//