Cellosaurus cell line GTL16R1 (CVCL

Cellosaurus GTL16R1 (CVCL_VS67)

Cross-references
Cell line name	GTL16R1
Synonyms	GTL16 R1
Accession	CVCL_VS67
Resource Identification Initiative	To cite this cell line use: GTL16R1 (RRID:CVCL_VS67)
Comments	Population: Japanese. Selected for resistance to: ChEBI; CHEBI_91425; 2-[4-[3-(6-quinolinylmethyl)-5-triazolo[4,5-b]pyrazinyl]-1-pyrazolyl]ethanol (PF-04217903). Omics: Transcriptomics; Microarray. Omics: Variations; SNP array analysis. Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations	Gene fusion; HGNC; HGNC:1097; BRAF + HGNC; HGNC:30646; SND1; Name(s)=SND1-BRAF (PubMed=22745804). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease	Gastric adenocarcinoma (NCIt: C4004)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_7668 (GTL-16)
Sex of cell	Female
Age at sampling	62Y
Category	Cancer cell line
Publications	PubMed=22745804; DOI=10.1371/journal.pone.0039653; PMCID=PMC3382171 Nathan V. Lee, Maruja E. Lira, Adam Pavlicek, Jing-Jing Ye, Dana Buckman, Shubha Bagrodia, Sreesha P. Srinivasa, Yong-Jun Zhao, Samuel Aparicio, Paul A. Rejto, James Gail Christensen, Keith A. Ching; A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through MAPK activation. PLoS ONE 7:e39653.1-e39653.12(2012)
Cell line databases/resources	cancercelllines; CVCL_VS67
Encyclopedic resources	Wikidata; Q93935412
Gene expression databases	GEO; GSM686016 GEO; GSM686035 GEO; GSM686036
Polymorphism and mutation databases	Progenetix; CVCL_VS67
Entry history
Entry creation	25-Feb-2019
Last entry update	10-Apr-2025
Version number	12