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Cellosaurus GTL16S5 (CVCL_VS69)

[Text version]
Cell line name GTL16S5
Synonyms GTL16 S5
Accession CVCL_VS69
Resource Identification Initiative To cite this cell line use: GTL16S5 (RRID:CVCL_VS69)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_91425; 2-[4-[3-(6-quinolinylmethyl)-5-triazolo[4,5-b]pyrazinyl]-1-pyrazolyl]ethanol (PF-04217903).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7668 (GTL-16)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=22745804; DOI=10.1371/journal.pone.0039653; PMCID=PMC3382171
Nathan V. Lee, Maruja E. Lira, Adam Pavlicek, Jing-Jing Ye, Dana Buckman, Shubha Bagrodia, Sreesha P. Srinivasa, Yong-Jun Zhao, Samuel Aparicio, Paul A. Rejto, James Gail Christensen, Keith A. Ching;
A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through MAPK activation.
PLoS ONE 7:e39653.1-e39653.12(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VS69
Encyclopedic resources Wikidata; Q93935419
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number9