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Cellosaurus MKN45/F2R (CVCL_QY39)

[Text version]
Cell line name MKN45/F2R
Accession CVCL_QY39
Resource Identification Initiative To cite this cell line use: MKN45/F2R (RRID:CVCL_QY39)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_46345; 5-fluorouracil (5-FU).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0434 (MKN45)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=19020740; DOI=10.3892/or_00000178
Yasuhiro Tsutani, Kazuhiro Yoshida, Yuichi Sanada, Yoshiyuki Wada, Kazuo Konishi, Masakazu Fukushima, Morihito Okada;
Decreased orotate phosphoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line.
Oncol. Rep. 20:1545-1551(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QY39
Encyclopedic resources Wikidata; Q54905825
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number10