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Cellosaurus MKN45cl85 (CVCL_D5HU)

[Text version]
Cell line name MKN45cl85
Accession CVCL_D5HU
Resource Identification Initiative To cite this cell line use: MKN45cl85 (RRID:CVCL_D5HU)
Comments Population: Japanese.
Characteristics: Parent cell line was injected subcutaneously in BALB/c nude mice. Cachexia-inducing tumor cells were harvested and re-injected into mice. This process was carried out 10 times (PubMed=23659450).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0434 (MKN45)
CVCL_D5HV (85As2)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line

PubMed=23659450; DOI=10.1080/01635581.2013.776089
Yanagihara K., Takigahira M., Mihara K., Kubo T., Morimoto C., Morita Y., Terawaki K., Uezono Y., Seyama T.
Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers.
Nutr. Cancer 65:578-589(2013)

PubMed=30410674; DOI=10.18632/oncotarget.26190
Terawaki K., Kashiwase Y., Uzu M., Nonaka M., Sawada Y., Miyano K., Higami Y., Yanagihara K., Yamamoto M., Uezono Y.
Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats.
Oncotarget 9:34748-34764(2018)

Gene expression databases GEO; GSM3097051
GEO; GSM3097052
GEO; GSM3097053
Entry history
Entry creation02-May-2024
Last entry update02-May-2024
Version number1