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Cellosaurus MKN45cl85 (CVCL_D5HU)

[Text version]
Cell line name MKN45cl85
Accession CVCL_D5HU
Resource Identification Initiative To cite this cell line use: MKN45cl85 (RRID:CVCL_D5HU)
Comments Population: Japanese.
Characteristics: Parent cell line was injected subcutaneously in BALB/c nude mice. Cachexia-inducing tumor cells were harvested and re-injected into mice. This process was carried out 10 times (PubMed=23659450).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0434 (MKN45)
Children:
CVCL_D5HV (85As2)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=23659450; DOI=10.1080/01635581.2013.776089
Kazuyoshi Yanagihara, Misato Takigahira, Keichiro Mihara, Takanori Kubo, Chie Morimoto, Yasuhiro Morita, Kiyoshi Terawaki, Yasuhito Uezono, Toshio Seyama;
Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers.
Nutr. Cancer 65:578-589(2013)

PubMed=30410674; DOI=10.18632/oncotarget.26190; PMCID=PMC6205166
Kiyoshi Terawaki, Yohei Kashiwase, Miaki Uzu, Miki Nonaka, Yumi Sawada, Kanako Miyano, Yoshikazu Higami, Kazuyoshi Yanagihara, Masahiro Yamamoto, Yasuhito Uezono;
Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats.
Oncotarget 9:34748-34764(2018)

Cross-references
Encyclopedic resources Wikidata; Q127382830
Gene expression databases GEO; GSM3097051
GEO; GSM3097052
GEO; GSM3097053
Entry history
Entry creation02-May-2024
Last entry update10-Apr-2025
Version number4