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Cellosaurus LS174T (CVCL_1384)

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Cell line name LS174T
Synonyms Ls174T; LS174t; Ls-174-T; LS-174-T; LS 174 T; LS-174T; Ls-174T; LS 174T; LS-174; LS174; Laboratory of Surgery 174T
Accession CVCL_1384
Secondary accession CVCL_D190
Resource Identification Initiative To cite this cell line use: LS174T (RRID:CVCL_1384)
Comments Group: Patented cell line.
Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: MD Anderson Cell Lines Project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-188.
Population: Caucasian.
Doubling time: 26 hours (Note=At 20th passage) (PubMed=1262041); 18-20 hours (PubMed=7370982); 38.01 hours (PubMed=25944804); ~30-40 hours (DSMZ=ACC-759).
Microsatellite instability: Instable (MSI) (PubMed=9000147; PubMed=10674020; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746).
Omics: Genomics; Whole exome sequencing.
Omics: Glycomics; N-glycan profiling.
Omics: Glycomics; O-glycan profiling.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: LV1747; Cosmic=1187310; PubMed=19132987.
Misspelling: L5174T; Note=Occasionally.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
HLA typing Source: ATCC=CL-188
Class I
HLA-AA*02
HLA-BB*13,50

Source: PubMed=8464898
Class I
HLA-AA*02,30

Source: PubMed=26589293
Class I
HLA-AA*30:01,30:01
HLA-BB*15:50,35:114
HLA-CC*04:01,06:02
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0397 (LS180)
Children:
CVCL_D240 (LiM6)CVCL_YJ85 (LINTERNA LS 174)CVCL_C4RY (LS174T-FX-R)
CVCL_0306 (LS174T-HM3)CVCL_6670 (LS174T-HM7)CVCL_B6NS (LS174T-LM12)
CVCL_J074 (LS174T-W4)CVCL_A5BI (LS174T/R)CVCL_2129 (MT-3 [Human contaminated breast cancer])
CVCL_0H88 (S1)CVCL_E0XI (Ubigene LS174T HMGB1 KO)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0009013/379; ATCC=CL-188; CCRID; CLS=300392; DSMZ=ACC-759; KCLB=10188; PubMed=11416159; PubMed=25877200; PubMed=25926053; TKG=TKG 0406

Markers:
AmelogeninX
CSF1PO10,11,13,14 (DSMZ=ACC-759)
10,13,14 (AddexBio=C0009013/379; ATCC=CL-188; PubMed=25926053)
10,14 (CCRID; CLS=300392; KCLB=10188; PubMed=25877200; TKG=TKG 0406)
D2S133818,21,22 (ATCC=CL-188; DSMZ=ACC-759)
18,22 (CLS=300392)
D3S135814,15,16,17 (DSMZ=ACC-759)
15,17 (ATCC=CL-188; CLS=300392; KCLB=10188; PubMed=25877200)
D5S81811,14,15 (DSMZ=ACC-759)
11,15 (AddexBio=C0009013/379; CCRID; CLS=300392; KCLB=10188; PubMed=25877200; PubMed=25926053; TKG=TKG 0406)
11,15,16 (ATCC=CL-188)
D7S82010,10.3 (TKG=TKG 0406)
10.3,11 (ATCC=CL-188; DSMZ=ACC-759; PubMed=25877200)
11 (AddexBio=C0009013/379; CCRID; CLS=300392; KCLB=10188; PubMed=25926053)
D8S117911,12,16 (CLS=300392)
12,15 (DSMZ=ACC-759)
12,15,16 (ATCC=CL-188)
12,16 (PubMed=25877200)
D13S3179,10,11 (DSMZ=ACC-759)
10 (AddexBio=C0009013/379; ATCC=CL-188; CCRID; PubMed=25877200; PubMed=25926053)
10,11 (CLS=300392; KCLB=10188; TKG=TKG 0406)
D16S53911,12,13 (DSMZ=ACC-759)
11,13 (AddexBio=C0009013/379; ATCC=CL-188; CCRID; CLS=300392; PubMed=25877200; PubMed=25926053; TKG=TKG 0406)
D18S5111,12,13 (DSMZ=ACC-759)
11,13 (ATCC=CL-188; CLS=300392; PubMed=25877200)
D19S43313,14,15 (CLS=300392)
13,15,23 (DSMZ=ACC-759)
14,15 (ATCC=CL-188)
D21S1129,30,31 (CLS=300392)
29,31 (ATCC=CL-188; PubMed=11416159; PubMed=25877200; PubMed=25926053)
30,31,31.3,32,32.3,33 (DSMZ=ACC-759)
FGA14,20,21,22 (DSMZ=ACC-759)
21,22 (ATCC=CL-188; CLS=300392; KCLB=10188; PubMed=25877200)
Penta D10
Penta E14,15,16 (ATCC=CL-188; DSMZ=ACC-759)
15,16 (CLS=300392; PubMed=25877200)
TH016,7
TPOX8,9
vWA15,16,17,18,19 (DSMZ=ACC-759)
15,17 (AddexBio=C0009013/379; CCRID; CLS=300392; KCLB=10188; PubMed=11416159; PubMed=25877200; PubMed=25926053; TKG=TKG 0406)
15,17,18 (ATCC=CL-188)

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/LS174T.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/colon-cancer-xenograft/ls174t-xenograft-model/
Publications

PubMed=1262041; DOI=10.1007/BF02796440
Baldwin H. Tom, Lynne P. Rutzky, Milda M. Jakstys, Ryoichi Oyasu, Celia I. Kaye, Barry Donald Kahan;
Human colonic adenocarcinoma cells. I. Establishment and description of a new line.
In Vitro 12:180-191(1976)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

Patent=US4228236
Milda M. Jakstys, Baldwin H. Tom, Barry Donald Kahan;
Process of producing carcinoembryonic antigen.
Patent number US4228236, 14-Oct-1980

PubMed=7370982
Lynne P. Rutzky, Celia I. Kaye, Michael Joseph Siciliano, Margaret Chao, Barry Donald Kahan;
Longitudinal karyotype and genetic signature analysis of cultured human colon adenocarcinoma cell lines LS180 and LS174T.
Cancer Res. 40:1443-1448(1980)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=6401685; DOI=10.1007/BF02617989
David Michael Halton, Ward Davis Peterson Jr., Bharati Hukku;
Cell culture quality control by rapid isoenzymatic characterization.
In Vitro 19:16-24(1983)

PubMed=6652615; DOI=10.1016/0165-4608(83)90092-4
Tchaw-Ren Chen, Robert J. Hay, Marvin L. Macy;
Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins.
Cancer Genet. Cytogenet. 10:351-362(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3664476
Shih-Fan Kuan, James C. Byrd, Carol Beth Basbaum, Young S. Kim;
Characterization of quantitative mucin variants from a human colon cancer cell line.
Cancer Res. 47:5715-5724(1987)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=3349466
Isabelle Chantret, Alain Barbat, Elisabeth Dussaulx, Michael G. Brattain, Alain Zweibaum;
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=1999484; DOI=10.1172/JCI115063; PMCID=PMC329898
Robert S. Bresalier, Yaron Niv, James C. Byrd, Quan-Yang Duh, Neil W. Toribara, Richard W. Rockwell, Raivir Dahiya, Young S. Kim;
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.
J. Clin. Invest. 87:1037-1045(1991)

PubMed=8422623; DOI=10.1002/1097-0142(19930115)71:2<315::AID-CNCR2820710208>3.0.CO;2-B
Lance M. Tibbetts, Craig M. Doremus, George N. Tzanakakis, Michael P. Vezeridis;
Liver metastases with 10 human colon carcinoma cell lines in nude mice and association with carcinoembryonic antigen production.
Cancer 71:315-321(1993)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Michael J. Browning, Peter Krausa, Andrew J. Rowan, David C. Bicknell, Julia Gwynaeth Bodmer, Walter Fred Bodmer;
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Aikou Okamoto, Douglas J. Demetrick, Elisa A. Spillare, Koichi Hagiwara, S. Perwez Hussain, William P. Bennett, Kathleen Forrester, Brenda Isen Gerwin, Manuel Serrano, David H. Beach, Curtis Craig Harris;
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=8895552; DOI=10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8
Laurent Suardet, Chuan Li, John Bertram Little;
Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.
Int. J. Cancer 68:126-131(1996)

PubMed=9000147
Paul-Henri Cottu, Francoise Muzeau, Anne Estreicher, Jean-Francois Flejou, Richard D. Iggo, Gilles Thomas, Richard Hamelin;
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Oncogene 13:2727-2730(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Mohammad Ilyas, Ian Philip Mark Tomlinson, Andrew J. Rowan, Massimo Pignatelli, Walter Fred Bodmer;
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3
Ja-Lok Ku, Kyong-Ah Yoon, D.-Y. Kim, Jae-Gahb Park;
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Eur. J. Cancer 35:1724-1729(1999)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Andrew J. Rowan, Hanan Lamlum, Mohammad Ilyas, James M.D. Wheeler, Jannes Straub, Angeliki Papadopoulou, David C. Bicknell, Walter Fred Bodmer, Ian Philip Mark Tomlinson;
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173
Wael M. Abdel-Rahman, Kanade Katsura, Willem Rens, Patricia A. Gorman, Denise Sheer, David C. Bicknell, Walter Fred Bodmer, Mark J. Arends, Andrew Hamilton Wyllie, Paul A.W. Edwards;
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11526487; DOI=10.1038/sj.onc.1204611
Jacqueline Gayet, Xiao-Ping Zhou, Alex Duval, Sandra Rolland, Jean-Marc Hoang, Paul-Henri Cottu, Richard Hamelin;
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Oncogene 20:5025-5032(2001)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=12606785; DOI=10.1124/mol.63.3.742
Oscar Briz, Rocio I.R. Macias, Marta Vallejo, Augusto Silva, Maria Angeles Serrano, Jose J.G. Marin;
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.
Mol. Pharmacol. 63:742-750(2003)

PubMed=15900046; DOI=10.1093/jnci/dji133
Tetsuo Mashima, Tomoko Oh-hara, Shigeo Sato, Mikiko Mochizuki, Yoshikazu Sugimoto, Kanami Yamazaki, Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Yuichi Ishikawa, Yo Kato ...Show all 14 authors... , Hiroshi Tomoda, Takao Yamori, Takashi Tsuruo; Show fewer authors
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
J. Natl. Cancer Inst. 97:765-777(2005)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420
Eva Maria Bandres Elizalde, Elena Cubedo, Xabier Agirre, Raquel Malumbres, Ruth Zarate, Natalia Ramirez, Ana Abajo, Alfons Navarro, Isabel Moreno, Mariano Monzo, Jesus Garcia-Foncillas;
Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues.
Mol. Cancer 5:29.1-29.10(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=19132987; DOI=10.1111/j.1600-0463.2008.01042.x
Yu-Qin Li, Yasuo Tanaka, Motohisa Tada, Rui Hua, Motoko Seto, Yoshinari Asaoka, Miki Ohta, Fumihiko Kanai, Haruhiko Yoshida, Takao Kawabe, Takaaki Sano ...Show all 14 authors... , Teiji Motojima, Osamu Yokosuka, Masao Omata; Show fewer authors
Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients.
APMIS 116:931-933(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514
Manickam Janakiraman, Efsevia Vakiani, Zhao-Shi Zeng, Christine A. Pratilas, Barry Stephen Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Marques Ricarte Filho, Yogindra Persaud ...Show all 21 authors... , Douglas A. Levine, James Alexander Fagin, Suresh C. Jhanwar, John M. Mariadason, Alex Lash, Marc Ladanyi, Leonard B. Saltz, Adriana Heguy, Philip B. Paty, David B. Solit; Show fewer authors
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225
Deeqa Ahmed, Peter W. Eide, Ina A. Eilertsen, Stine A. Danielsen, Mette Eknaes, Merete Hektoen, Guro Elisabeth Lind, Ragnhild Adelheid Lothe;
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:e71.1-e71.8(2013)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=24840470; DOI=10.1016/j.jprot.2014.05.002
Jenny H.L. Chik, Jerry Zhou, Edward S.X. Moh, Richard Christopherson, Stephen J. Clarke, Mark P. Molloy, Nicolle H. Packer;
Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.
J. Proteomics 108:146-162(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531
Stephanie Holst, Anna J.M. Deuss, Gabi W. van Pelt, Sandra Johanna van Vliet, Juan J. Garcia-Vallejo, Carolien A.M. Koeleman, Andre M. Deelder, Wilma E. Mesker, Rob A.E.M. Tollenaar, Yoann Rombouts, Manfred Wuhrer;
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Cross-references
Cell line collections (Providers) AddexBio; C0009013/379
ATCC; CCL-188 - Discontinued
ATCC; CL-188
BCRC; 60053
CCTCC; GDC0135
CLS; 300392
DSMZ; ACC-759
ECACC; 87060401
KCB; KCB 200829YJ
KCLB; 10188
NCBI_Iran; C568
RCB; RCB1961 - Discontinued
TKG; TKG 0406
Ubigene; YC-C088
Cell line databases/resources CLO; CLO_0007393
CLO; CLO_0007403
MCCL; MCC:0000504
CLDB; cl3261
cancercelllines; CVCL_1384
CCRID; 1101HUM-PUMC000248
CCRID; 3101HUMTCHu32
CCRID; 4201HUM-CCTCC00135
Cell_Model_Passport; SIDM01200
ColonAtlas; LS174T
DSMZCellDive; ACC-759
IGRhCellID; LS174T
LINCS_LDP; LCL-1182
Lonza; 1127
TOKU-E; 2235
Anatomy/cell type resources BTO; BTO_0001553
Biological sample resources BioSample; SAMN03470826
BioSample; SAMN03471296
Chemistry resources ChEMBL-Cells; CHEMBL3307536
ChEMBL-Targets; CHEMBL614097
PharmacoDB; LS174T_862_2019
PubChem_Cell_line; CVCL_1384
Encyclopedic resources Wikidata; Q54903053
Experimental variables resources EFO; EFO_0002227
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
GEO; GSM513911
GEO; GSM514297
GEO; GSM741264
GEO; GSM784021
GEO; GSM827345
GEO; GSM1346883
GEO; GSM1374632
GEO; GSM1374633
GEO; GSM1448164
GEO; GSM2550009
Metabolomic databases MetaboLights; MTBLS227
Polymorphism and mutation databases Cosmic; 711255
Cosmic; 719679
Cosmic; 724843
Cosmic; 738927
Cosmic; 873703
Cosmic; 875424
Cosmic; 876717
Cosmic; 887219
Cosmic; 889533
Cosmic; 907793
Cosmic; 934563
Cosmic; 948131
Cosmic; 948856
Cosmic; 985998
Cosmic; 995405
Cosmic; 1043822
Cosmic; 1057755
Cosmic; 1066210
Cosmic; 1122328
Cosmic; 1132565
Cosmic; 1132692
Cosmic; 1184087
Cosmic; 1184334
Cosmic; 1187310
Cosmic; 1312305
Cosmic; 1479573
Cosmic; 1486134
Cosmic; 1524341
Cosmic; 1676738
Cosmic; 1708419
Cosmic; 1805263
Cosmic; 2301546
Cosmic; 2301997
Cosmic; 2646768
Cosmic; 2651866
Cosmic; 2668256
Cosmic; 2760087
Cosmic; 2787546
IARC_TP53; 21478
IARC_TP53; 21708
Progenetix; CVCL_1384
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number49