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Cellosaurus LS174T/R (CVCL_A5BI)

[Text version]
Cell line name LS174T/R
Synonyms LS 174T/R
Accession CVCL_A5BI
Resource Identification Initiative To cite this cell line use: LS174T/R (RRID:CVCL_A5BI)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=12606785; DOI=10.1124/mol.63.3.742
Briz O., Macias R.I.R., Vallejo M., Silva A., Serrano M.A., Marin J.J.G.
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.
Mol. Pharmacol. 63:742-750(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5BI
Encyclopedic resources Wikidata; Q107115875
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5