Cellosaurus logo
expasy logo

Cellosaurus LS174T/R (CVCL_A5BI)

[Text][XML][JSON]
Cell line name LS174T/R
Synonyms LS 174T/R
Accession CVCL_A5BI
Resource Identification Initiative To cite this cell line use: LS174T/R (RRID:CVCL_A5BI)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=12606785; DOI=10.1124/mol.63.3.742
Oscar Briz, Rocio I.R. Macias, Marta Vallejo, Augusto Silva, Maria Angeles Serrano, Jose J.G. Marin;
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.
Mol. Pharmacol. 63:742-750(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5BI
Encyclopedic resources Wikidata; Q107115875
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number6