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Cellosaurus LS174T-W4 (CVCL_J074)

[Text version]
Cell line name LS174T-W4
Synonyms Ls174T-W4; W4
Accession CVCL_J074
Resource Identification Initiative To cite this cell line use: LS174T-W4 (RRID:CVCL_J074)
Comments Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line

PubMed=19386264; DOI=10.1016/j.devcel.2009.01.016
ten Klooster J.P., Jansen M., Yuan J., Oorschot V.M.J., Begthel H., Di Giacomo V., Colland F., de Koning J.P., Maurice M.M., Hornbeck P., Clevers H.C.
Mst4 and ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
Dev. Cell 16:551-562(2009)

Cell line databases/resources cancercelllines; CVCL_J074
Encyclopedic resources Wikidata; Q54903056
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number16