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Cellosaurus LS174T-W4 (CVCL_J074)

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Cell line name LS174T-W4
Synonyms Ls174T-W4; W4
Accession CVCL_J074
Resource Identification Initiative To cite this cell line use: LS174T-W4 (RRID:CVCL_J074)
Comments Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=19386264; DOI=10.1016/j.devcel.2009.01.016
Jean Paul ten Klooster, Marnix Jansen, Jin Yuan, Viola M.J. Oorschot, Harry Begthel, Valeria Di Giacomo, Frederic Colland, John P. de Koning, Madelon M. Maurice, Peter Hornbeck, Hans Cornelius Clevers;
Mst4 and ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
Dev. Cell 16:551-562(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_J074
Encyclopedic resources Wikidata; Q54903056
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number17