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Cellosaurus LiM6 (CVCL_D240)

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Cell line name LiM6
Synonyms LIM6; LiM-6; LS-LiM6; Ls-LiM6; LS LiM 6; LS LiM6; LSLiM6
Accession CVCL_D240
Resource Identification Initiative To cite this cell line use: LiM6 (RRID:CVCL_D240)
Comments Population: Caucasian.
Characteristics: Has high liver-metastasizing ability during cecal growth, was established from parent cell line by serially selecting cells which metastasized from cecum to liver (PubMed=1999484).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Children:
CVCL_B6NT (LIM6-TR)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=3032811; DOI=10.1002/ijc.2910390514
Robert S. Bresalier, Steven E. Raper, Erkki S. Hujanen, Young S. Kim;
A new animal model for human colon cancer metastasis.
Int. J. Cancer 39:625-630(1987)

PubMed=1999484; DOI=10.1172/JCI115063; PMCID=PMC329898
Robert S. Bresalier, Yaron Niv, James C. Byrd, Quan-Yang Duh, Neil W. Toribara, Richard W. Rockwell, Raivir Dahiya, Young S. Kim;
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.
J. Clin. Invest. 87:1037-1045(1991)

PubMed=21941373; DOI=10.1038/cdd.2011.123; PMCID=PMC3246527
Nachman Mazurek, James C. Byrd, Yun-Jie Sun, Margarete Hafley, Karen Ramirez, Jared Burks, Robert S. Bresalier;
Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells.
Cell Death Differ. 19:523-533(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D240
Anatomy/cell type resources BTO; BTO_0004866
Encyclopedic resources Wikidata; Q54902542
Polymorphism and mutation databases Cosmic; 1132697
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number19