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Cellosaurus LIM6-TR (CVCL_B6NT)

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Cell line name LIM6-TR
Synonyms LIM6-TRAIL Resistant
Accession CVCL_B6NT
Resource Identification Initiative To cite this cell line use: LIM6-TR (RRID:CVCL_B6NT)
Comments Population: Caucasian.
Characteristics: Has high liver-metastasizing ability during cecal growth (from parent cell line).
Selected for resistance to: UniProtKB; P50591; Human TNFSF10/CD253.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D240 (LiM6)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=21941373; DOI=10.1038/cdd.2011.123; PMCID=PMC3246527
Nachman Mazurek, James C. Byrd, Yun-Jie Sun, Margarete Hafley, Karen Ramirez, Jared Burks, Robert S. Bresalier;
Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells.
Cell Death Differ. 19:523-533(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B6NT
Encyclopedic resources Wikidata; Q112929998
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number6