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Cellosaurus LS174T-HM7 (CVCL_6670)

[Text version]
Cell line name LS174T-HM7
Synonyms HM7; HM-7; HM 7; LS174T-High Mucin 7
Accession CVCL_6670
Resource Identification Initiative To cite this cell line use: LS174T-HM7 (RRID:CVCL_6670)
Comments Population: Caucasian.
Characteristics: Produces high amount of mucin in culture (PubMed=3664476).
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*30:01,30:01
HLA-BB*15:34,35:03
HLA-CC*04:01,06:02
Class II
HLA-DQDQB1*05:01,05:01
HLA-DRDRB1*01:01,01:01
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,13
D3S135816,17
D5S81811,16
D7S82010.3,11
D8S117912,16
D13S31710,11
D16S53911,13
D18S5111,12
D21S1129,31
FGA21,22
Penta D10
Penta E15,16
TH016,7
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=3664476
Kuan S.-F., Byrd J.C., Basbaum C.B., Kim Y.S.
Characterization of quantitative mucin variants from a human colon cancer cell line.
Cancer Res. 47:5715-5724(1987)

PubMed=1999484; DOI=10.1172/JCI115063
Bresalier R.S., Niv Y., Byrd J.C., Duh Q.-Y., Toribara N.W., Rockwell R.W., Dahiya R., Kim Y.S.
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.
J. Clin. Invest. 87:1037-1045(1991)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6670
ColonAtlas; HM7
Anatomy/cell type resources BTO; BTO:0002921
Biological sample resources BioSample; SAMN03472364
Chemistry resources PharmacoDB; HM7_551_2019
Encyclopedic resources Wikidata; Q54903055
Experimental variables resources EFO; EFO_0006787
Gene expression databases ArrayExpress; E-MTAB-2706
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22