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Cellosaurus LS174T-HM7 (CVCL_6670)

[Text version]
Cell line name LS174T-HM7
Synonyms HM7; HM-7; HM 7; LS174T-High Mucin 7
Accession CVCL_6670
Resource Identification Initiative To cite this cell line use: LS174T-HM7 (RRID:CVCL_6670)
Comments Population: Caucasian.
Characteristics: Produces high amount of mucin in culture (PubMed=3664476).
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*30:01,30:01
HLA-BB*15:34,35:03
HLA-CC*04:01,06:02
Class II
HLA-DQDQB1*05:01,05:01
HLA-DRDRB1*01:01,01:01
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,13
D3S135816,17
D5S81811,16
D7S82010.3,11
D8S117912,16
D13S31710,11
D16S53911,13
D18S5111,12
D21S1129,31
FGA21,22
Penta D10
Penta E15,16
TH016,7
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=3664476
Shih-Fan Kuan, James C. Byrd, Carol Beth Basbaum, Young S. Kim;
Characterization of quantitative mucin variants from a human colon cancer cell line.
Cancer Res. 47:5715-5724(1987)

PubMed=1999484; DOI=10.1172/JCI115063; PMCID=PMC329898
Robert S. Bresalier, Yaron Niv, James C. Byrd, Quan-Yang Duh, Neil W. Toribara, Richard W. Rockwell, Raivir Dahiya, Young S. Kim;
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.
J. Clin. Invest. 87:1037-1045(1991)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6670
ColonAtlas; HM7
Anatomy/cell type resources BTO; BTO_0002921
Biological sample resources BioSample; SAMN03472364
Chemistry resources PharmacoDB; HM7_551_2019
Encyclopedic resources Wikidata; Q54903055
Experimental variables resources EFO; EFO_0006787
Gene expression databases ArrayExpress; E-MTAB-2706
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24