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Cellosaurus LS174T-LM12 (CVCL_B6NS)

[Text version]
Cell line name LS174T-LM12
Synonyms LM12; LM 12; LS174T-Low Mucin 12
Accession CVCL_B6NS
Resource Identification Initiative To cite this cell line use: LS174T-LM12 (RRID:CVCL_B6NS)
Comments Population: Caucasian.
Characteristics: Produces low amount of mucin in culture (PubMed=3664476).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line

Kuan S.-F., Byrd J.C., Basbaum C.B., Kim Y.S.
Characterization of quantitative mucin variants from a human colon cancer cell line.
Cancer Res. 47:5715-5724(1987)

PubMed=1999484; DOI=10.1172/JCI115063
Bresalier R.S., Niv Y., Byrd J.C., Duh Q.-Y., Toribara N.W., Rockwell R.W., Dahiya R., Kim Y.S.
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.
J. Clin. Invest. 87:1037-1045(1991)

Cell line databases/resources cancercelllines; CVCL_B6NS
Encyclopedic resources Wikidata; Q112930022
Entry history
Entry creation17-Mar-2022
Last entry update05-Oct-2023
Version number5