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Cellosaurus LS174T-LM12 (CVCL_B6NS)

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Cell line name LS174T-LM12
Synonyms LM12; LM 12; LS174T-Low Mucin 12
Accession CVCL_B6NS
Resource Identification Initiative To cite this cell line use: LS174T-LM12 (RRID:CVCL_B6NS)
Comments Population: Caucasian.
Characteristics: Produces low amount of mucin in culture (PubMed=3664476).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=3664476
Shih-Fan Kuan, James C. Byrd, Carol Beth Basbaum, Young S. Kim;
Characterization of quantitative mucin variants from a human colon cancer cell line.
Cancer Res. 47:5715-5724(1987)

PubMed=1999484; DOI=10.1172/JCI115063; PMCID=PMC329898
Robert S. Bresalier, Yaron Niv, James C. Byrd, Quan-Yang Duh, Neil W. Toribara, Richard W. Rockwell, Raivir Dahiya, Young S. Kim;
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.
J. Clin. Invest. 87:1037-1045(1991)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B6NS
Encyclopedic resources Wikidata; Q112930022
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number6