ID   LS174T-LM12
AC   CVCL_B6NS
SY   LM12; LM 12; LS174T-Low Mucin 12
DR   cancercelllines; CVCL_B6NS
DR   Wikidata; Q112930022
RX   PubMed=1999484;
RX   PubMed=3664476;
CC   Population: Caucasian.
CC   Characteristics: Produces low amount of mucin in culture (PubMed=3664476).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1384 ! LS174T
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=1999484; DOI=10.1172/JCI115063;
RA   Bresalier R.S., Niv Y., Byrd J.C., Duh Q.-Y., Toribara N.W.,
RA   Rockwell R.W., Dahiya R., Kim Y.S.;
RT   "Mucin production by human colonic carcinoma cells correlates with
RT   their metastatic potential in animal models of colon cancer
RT   metastasis.";
RL   J. Clin. Invest. 87:1037-1045(1991).
//
RX   PubMed=3664476;
RA   Kuan S.-F., Byrd J.C., Basbaum C.B., Kim Y.S.;
RT   "Characterization of quantitative mucin variants from a human colon
RT   cancer cell line.";
RL   Cancer Res. 47:5715-5724(1987).
//