ID   LS174T-LM12
AC   CVCL_B6NS
SY   LM12; LM 12; LS174T-Low Mucin 12
DR   cancercelllines; CVCL_B6NS
DR   Wikidata; Q112930022
RX   PubMed=1999484;
RX   PubMed=3664476;
CC   Population: Caucasian.
CC   Characteristics: Produces low amount of mucin in culture (PubMed=3664476).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1384 ! LS174T
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 19-12-24; Version: 6
//
RX   PubMed=3664476;
RA   Kuan, Shih-Fan
RA   Byrd, James C.
RA   Basbaum, Carol Beth
RA   Kim, Young S.
RT   "Characterization of quantitative mucin variants from a human colon
RT   cancer cell line.";
RL   Cancer Res. 47:5715-5724(1987).
//
RX   PubMed=1999484; DOI=10.1172/JCI115063; PMCID=PMC329898;
RA   Bresalier, Robert S.
RA   Niv, Yaron
RA   Byrd, James C.
RA   Duh, Quan-Yang
RA   Toribara, Neil W.
RA   Rockwell, Richard W.
RA   Dahiya, Raivir
RA   Kim, Young S.
RT   "Mucin production by human colonic carcinoma cells correlates with
RT   their metastatic potential in animal models of colon cancer
RT   metastasis.";
RL   J. Clin. Invest. 87:1037-1045(1991).
//