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Cellosaurus LS174T-HM3 (CVCL_0306)

[Text version]
Cell line name LS174T-HM3
Synonyms HM3; HM3-MUC2; LS174T-High Mucin 3
Accession CVCL_0306
Resource Identification Initiative To cite this cell line use: LS174T-HM3 (RRID:CVCL_0306)
Comments Population: Caucasian.
Characteristics: Produces high amount of mucin in culture (PubMed=3664476).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=3664476
Kuan S.-F., Byrd J.C., Basbaum C.B., Kim Y.S.
Characterization of quantitative mucin variants from a human colon cancer cell line.
Cancer Res. 47:5715-5724(1987)

Cross-references
Cell line databases/resources MCCL; MCC:0000198
cancercelllines; CVCL_0306
Encyclopedic resources Wikidata; Q54903054
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18