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Cellosaurus 1321N1 (CVCL_0110)

[Text version]
Cell line name 1321N1
Synonyms 1321-N1; 1321 N1
Accession CVCL_0110
Resource Identification Initiative To cite this cell line use: 1321N1 (RRID:CVCL_0110)
Comments Problematic cell line: Contaminated. Grand-parent cell line (U-118MG) has been shown to be a U-138MG derivative.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.06
Native American0
East Asian, North1.62
East Asian, South0
South Asian0
European, North96.5
European, South0.81
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D317 (1181N1)
Children:
CVCL_5I82 (1321N1 (+Galpha16) AequoScreen)CVCL_5I83 (1321N1 AequoScreen)CVCL_C3IQ (1321N1 MRTFA KO)
CVCL_KU48 (1321N1 P2RY1 Gq)CVCL_C3IR (1321N1 RHOA KO)CVCL_C3IS (1321N1 YAP1 KO)
CVCL_ZD90 (1321N1-HA-P2Y1)CVCL_ZD94 (1321N1-HA-P2Y11)CVCL_ZD95 (1321N1-HA-P2Y12)
CVCL_ZD96 (1321N1-HA-P2Y13)CVCL_ZD97 (1321N1-HA-P2Y14)CVCL_ZD91 (1321N1-HA-P2Y2)
CVCL_ZD92 (1321N1-HA-P2Y4)CVCL_ZD93 (1321N1-HA-P2Y6)CVCL_D4EB (1321N1-MFSD1-KO-c12)
CVCL_D4EC (1321N1-MFSD1-KO-c5)CVCL_D4ED (1321N1-NIPAL3-KO-c1)CVCL_D4EE (1321N1-NIPAL3-KO-c3)
CVCL_D4EF (1321N1-NPC1-KO-c10)CVCL_D4EG (1321N1-NPC1-KO-c8)CVCL_D4EH (1321N1-SLC16A11-KO-c17)
CVCL_D4EI (1321N1-SLC16A11-KO-c8)CVCL_D4EJ (1321N1-SLC16A2-KO-c3)CVCL_D4EK (1321N1-SLC16A2-KO-c6)
CVCL_D4EL (1321N1-SLC17A7-KO-c13)CVCL_D4EM (1321N1-SLC17A7-KO-c16)CVCL_D4EN (1321N1-SLC22A4-KO-c10)
CVCL_D4EP (1321N1-SLC22A4-KO-c11)CVCL_D4EQ (1321N1-SLC23A3-KO-c6)CVCL_D4ER (1321N1-SLC23A3-KO-c7)
CVCL_D4ES (1321N1-SLC24A5-KO-c4)CVCL_D4ET (1321N1-SLC25A21-KO-c13)CVCL_D4EU (1321N1-SLC25A21-KO-c7)
CVCL_D4EV (1321N1-SLC26A10-KO-c2)CVCL_D4EW (1321N1-SLC26A10-KO-c5)CVCL_D4EX (1321N1-SLC26A2-KO-c3)
CVCL_D4EY (1321N1-SLC26A2-KO-c7)CVCL_D4EZ (1321N1-SLC2A10-KO-c11)CVCL_D4F0 (1321N1-SLC2A10-KO-c6)
CVCL_D4F1 (1321N1-SLC2A3-KO-c18)CVCL_D4F2 (1321N1-SLC2A3-KO-c21)CVCL_D4F3 (1321N1-SLC2A3-KO-c4)
CVCL_D4F4 (1321N1-SLC35F5-KO-c10)CVCL_D4F5 (1321N1-SLC35F5-KO-c11)CVCL_D4F6 (1321N1-SLC35G2-KO-c11)
CVCL_D4F7 (1321N1-SLC35G2-KO-c13)CVCL_D4F8 (1321N1-SLC37A2-KO-c3)CVCL_D4F9 (1321N1-SLC37A2-KO-c7)
CVCL_D4FA (1321N1-SLC43A3-KO-c3)CVCL_D4FB (1321N1-SLC43A3-KO-c6)CVCL_D4FC (1321N1-SLC4A8-KO-c4)
CVCL_D4FD (1321N1-SLC4A8-KO-c6)CVCL_D4FE (1321N1-SLC6A9-KO-c3)CVCL_D4FF (1321N1-SLC6A9-KO-c5)
CVCL_D4FG (1321N1-SLC8A1-KO-c4)CVCL_D4FH (1321N1-SLC8A1-KO-c7)CVCL_D4FI (1321N1-SLC9A9-KO-c10)
CVCL_D4FJ (1321N1-SLC9A9-KO-c6)CVCL_D4FK (1321N1-SV2A-KO-c14)CVCL_D4FL (1321N1-SV2A-KO-c17)
CVCL_D4FM (1321N1-TUSC3-KO-c10)CVCL_D4FN (1321N1-TUSC3-KO-c4)CVCL_D4FP (1321N1-UCP2-KO-c3)
CVCL_D4FQ (1321N1-UCP2-KO-c5)CVCL_D4FR (1321N1-UCP3-KO-c13)CVCL_D4FS (1321N1-UCP3-KO-c16)
CVCL_C9F6 (1321N1/Cas9-hyg)CVCL_KT02 (1321N1/FFAR1)CVCL_H355 (1321N1/P2Y1)
CVCL_H356 (1321N1/P2Y11)CVCL_H357 (1321N1/P2Y12/Galpha15)CVCL_H358 (1321N1/P2Y2)
CVCL_H359 (1321N1/P2Y4)CVCL_H360 (1321N1/P2Y6)CVCL_KU71 (cAMP Hunter 1321N1 CALCR-RAMP3 Gs)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): ECACC=86030402; IZSLER=BS TCL 109; PubMed=17254797; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11 (PubMed=17254797)
11,12 (ECACC=86030402; IZSLER=BS TCL 109; PubMed=25877200)
D2S133823,25
D3S135815
D5S81811
D7S8209
D8S117914,15
D13S3179,11
D16S53912,13
D18S5113,14
D19S43313
D21S1127 (PubMed=17254797)
27,32.2 (IZSLER=BS TCL 109; PubMed=25877200)
FGA18,23,24
Penta D10,13
Penta E7
TH016
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/1321n1/
Publications

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=29887596; DOI=10.1038/s41388-018-0301-5; PMCID=PMC6195840
Olivia M. Yu, Jorge A. Benitez, Steven W. Plouffe, Daniel Ryback, Andrea Klein, Jeff Smith, Jason Greenbaum, Benjamin Delatte, Anjana Rao, Kun-Liang Guan, Frank B. Furnari ...Show all 14 authors... , Olga Meiri Chaim, Shigeki Miyamoto, Joan Heller Brown; Show fewer authors
YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.
Oncogene 37:5492-5507(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ECACC; 86030402
IZSLER; BS TCL 109
NCBI_Iran; C118
Cell line databases/resources CLO; CLO_0001072
MCCL; MCC:0000001
CLDB; cl5
cancercelllines; CVCL_0110
Cell_Model_Passport; SIDM01967
DepMap; ACH-001000
LINCS_LDP; LCL-1393
Anatomy/cell type resources BTO; BTO_0003605
Biological sample resources BioSample; SAMN03471026
Chemistry resources PharmacoDB; 1321N1_2_2019
Encyclopedic resources Wikidata; Q54581478
Gene expression databases GEO; GSM827421
GEO; GSM886835
GEO; GSM887898
GEO; GSM1374373
GEO; GSM3034453
GEO; GSM3034454
GEO; GSM3034455
GEO; GSM3034456
GEO; GSM3034457
GEO; GSM3034458
Polymorphism and mutation databases IARC_TP53; 21148
Progenetix; CVCL_0110
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number35