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Cellosaurus 1321N1-HA-P2Y4 (CVCL_ZD92)

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Cell line name 1321N1-HA-P2Y4
Accession CVCL_ZD92
Resource Identification Initiative To cite this cell line use: 1321N1-HA-P2Y4 (RRID:CVCL_ZD92)
Comments Problematic cell line: Contaminated. Ancestral cell line (U-118MG) has been shown to be a U-138MG derivative.
Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8542; P2RY4 (Note=With a N-terminal HA tag).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0110 (1321N1)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=10779375
Charles Kennedy, Ai-Dong Qi, Christopher L. Herold, T. Kendall Harden, Robert A. Nicholas;
ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Mol. Pharmacol. 57:926-931(2000)

Cross-references
Cell line collections (Providers) ABM; T6191
Kerafast; ENC020
Cell line databases/resources cancercelllines; CVCL_ZD92
Encyclopedic resources Wikidata; Q98125091
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number12