ID 1321N1 AC CVCL_0110 SY 1321-N1; 1321 N1 DR BTO; BTO_0003605 DR CLO; CLO_0001072 DR MCCL; MCC:0000001 DR CLDB; cl5 DR BioSample; SAMN03471026 DR cancercelllines; CVCL_0110 DR Cell_Model_Passport; SIDM01967 DR DepMap; ACH-001000 DR ECACC; 86030402 DR GEO; GSM827421 DR GEO; GSM886835 DR GEO; GSM887898 DR GEO; GSM1374373 DR GEO; GSM3034453 DR GEO; GSM3034454 DR GEO; GSM3034455 DR GEO; GSM3034456 DR GEO; GSM3034457 DR GEO; GSM3034458 DR IARC_TP53; 21148 DR IZSLER; BS TCL 109 DR LINCS_LDP; LCL-1393 DR NCBI_Iran; C118 DR PharmacoDB; 1321N1_2_2019 DR Progenetix; CVCL_0110 DR Wikidata; Q54581478 RX PubMed=17254797; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=25877200; RX PubMed=29887596; RX PubMed=30894373; RX PubMed=31068700; WW Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/1321n1/ CC Problematic cell line: Contaminated. Grand-parent cell line (U-118MG) has been shown to be a U-138MG derivative. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Population: Caucasian. CC Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line). CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.06%; Native American=0%; East Asian, North=1.62%; East Asian, South=0%; South Asian=0%; European, North=96.5%; European, South=0.81% (PubMed=30894373). CC Derived from site: In situ; Brain; UBERON=UBERON_0000955. ST Source(s): ECACC=86030402; IZSLER=BS TCL 109; PubMed=17254797; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 11 (PubMed=17254797) ST CSF1PO: 11,12 (ECACC=86030402; IZSLER=BS TCL 109; PubMed=25877200) ST D13S317: 9,11 ST D16S539: 12,13 ST D18S51: 13,14 ST D19S433: 13 ST D21S11: 27 (PubMed=17254797) ST D21S11: 27,32.2 (IZSLER=BS TCL 109; PubMed=25877200) ST D2S1338: 23,25 ST D3S1358: 15 ST D5S818: 11 ST D7S820: 9 ST D8S1179: 14,15 ST FGA: 18,23,24 ST Penta D: 10,13 ST Penta E: 7 ST TH01: 6 ST TPOX: 8 ST vWA: 18 DI NCIt; C60781; Astrocytoma DI ORDO; Orphanet_94; Astrocytoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_D317 ! 1181N1 SX Male AG 47Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 35 CH CVCL_5I82 ! 1321N1 (+Galpha16) AequoScreen CH CVCL_5I83 ! 1321N1 AequoScreen CH CVCL_C3IQ ! 1321N1 MRTFA KO CH CVCL_KU48 ! 1321N1 P2RY1 Gq CH CVCL_C3IR ! 1321N1 RHOA KO CH CVCL_C3IS ! 1321N1 YAP1 KO CH CVCL_ZD90 ! 1321N1-HA-P2Y1 CH CVCL_ZD94 ! 1321N1-HA-P2Y11 CH CVCL_ZD95 ! 1321N1-HA-P2Y12 CH CVCL_ZD96 ! 1321N1-HA-P2Y13 CH CVCL_ZD97 ! 1321N1-HA-P2Y14 CH CVCL_ZD91 ! 1321N1-HA-P2Y2 CH CVCL_ZD92 ! 1321N1-HA-P2Y4 CH CVCL_ZD93 ! 1321N1-HA-P2Y6 CH CVCL_D4EB ! 1321N1-MFSD1-KO-c12 CH CVCL_D4EC ! 1321N1-MFSD1-KO-c5 CH CVCL_D4ED ! 1321N1-NIPAL3-KO-c1 CH CVCL_D4EE ! 1321N1-NIPAL3-KO-c3 CH CVCL_D4EF ! 1321N1-NPC1-KO-c10 CH CVCL_D4EG ! 1321N1-NPC1-KO-c8 CH CVCL_D4EH ! 1321N1-SLC16A11-KO-c17 CH CVCL_D4EI ! 1321N1-SLC16A11-KO-c8 CH CVCL_D4EJ ! 1321N1-SLC16A2-KO-c3 CH CVCL_D4EK ! 1321N1-SLC16A2-KO-c6 CH CVCL_D4EL ! 1321N1-SLC17A7-KO-c13 CH CVCL_D4EM ! 1321N1-SLC17A7-KO-c16 CH CVCL_D4EN ! 1321N1-SLC22A4-KO-c10 CH CVCL_D4EP ! 1321N1-SLC22A4-KO-c11 CH CVCL_D4EQ ! 1321N1-SLC23A3-KO-c6 CH CVCL_D4ER ! 1321N1-SLC23A3-KO-c7 CH CVCL_D4ES ! 1321N1-SLC24A5-KO-c4 CH CVCL_D4ET ! 1321N1-SLC25A21-KO-c13 CH CVCL_D4EU ! 1321N1-SLC25A21-KO-c7 CH CVCL_D4EV ! 1321N1-SLC26A10-KO-c2 CH CVCL_D4EW ! 1321N1-SLC26A10-KO-c5 CH CVCL_D4EX ! 1321N1-SLC26A2-KO-c3 CH CVCL_D4EY ! 1321N1-SLC26A2-KO-c7 CH CVCL_D4EZ ! 1321N1-SLC2A10-KO-c11 CH CVCL_D4F0 ! 1321N1-SLC2A10-KO-c6 CH CVCL_D4F1 ! 1321N1-SLC2A3-KO-c18 CH CVCL_D4F2 ! 1321N1-SLC2A3-KO-c21 CH CVCL_D4F3 ! 1321N1-SLC2A3-KO-c4 CH CVCL_D4F4 ! 1321N1-SLC35F5-KO-c10 CH CVCL_D4F5 ! 1321N1-SLC35F5-KO-c11 CH CVCL_D4F6 ! 1321N1-SLC35G2-KO-c11 CH CVCL_D4F7 ! 1321N1-SLC35G2-KO-c13 CH CVCL_D4F8 ! 1321N1-SLC37A2-KO-c3 CH CVCL_D4F9 ! 1321N1-SLC37A2-KO-c7 CH CVCL_D4FA ! 1321N1-SLC43A3-KO-c3 CH CVCL_D4FB ! 1321N1-SLC43A3-KO-c6 CH CVCL_D4FC ! 1321N1-SLC4A8-KO-c4 CH CVCL_D4FD ! 1321N1-SLC4A8-KO-c6 CH CVCL_D4FE ! 1321N1-SLC6A9-KO-c3 CH CVCL_D4FF ! 1321N1-SLC6A9-KO-c5 CH CVCL_D4FG ! 1321N1-SLC8A1-KO-c4 CH CVCL_D4FH ! 1321N1-SLC8A1-KO-c7 CH CVCL_D4FI ! 1321N1-SLC9A9-KO-c10 CH CVCL_D4FJ ! 1321N1-SLC9A9-KO-c6 CH CVCL_D4FK ! 1321N1-SV2A-KO-c14 CH CVCL_D4FL ! 1321N1-SV2A-KO-c17 CH CVCL_D4FM ! 1321N1-TUSC3-KO-c10 CH CVCL_D4FN ! 1321N1-TUSC3-KO-c4 CH CVCL_D4FP ! 1321N1-UCP2-KO-c3 CH CVCL_D4FQ ! 1321N1-UCP2-KO-c5 CH CVCL_D4FR ! 1321N1-UCP3-KO-c13 CH CVCL_D4FS ! 1321N1-UCP3-KO-c16 CH CVCL_C9F6 ! 1321N1/Cas9-hyg CH CVCL_KT02 ! 1321N1/FFAR1 CH CVCL_H355 ! 1321N1/P2Y1 CH CVCL_H356 ! 1321N1/P2Y11 CH CVCL_H357 ! 1321N1/P2Y12/Galpha15 CH CVCL_H358 ! 1321N1/P2Y2 CH CVCL_H359 ! 1321N1/P2Y4 CH CVCL_H360 ! 1321N1/P2Y6 CH CVCL_KU71 ! cAMP Hunter 1321N1 CALCR-RAMP3 Gs // RX PubMed=29887596; DOI=10.1038/s41388-018-0301-5; PMCID=PMC6195840; RA Yu, Olivia M. RA Benitez, Jorge A. RA Plouffe, Steven W. RA Ryback, Daniel RA Klein, Andrea RA Smith, Jeff RA Greenbaum, Jason RA Delatte, Benjamin RA Rao, Anjana RA Guan, Kun-Liang RA Furnari, Frank B. RA Chaim, Olga Meiri RA Miyamoto, Shigeki RA Brown, Joan Heller RT "YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene RT expression, are critical for glioblastoma tumorigenicity."; RL Oncogene 37:5492-5507(2018). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001; RA Azari, Shahram RA Ahmadi, Nahid RA Jeddi-Tehrani, Mahmood RA Shokri, Fazel RT "Profiling and authentication of human cell lines using short tandem RT repeat (STR) loci: report from the National Cell Bank of Iran."; RL Biologicals 35:195-202(2007). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). //