Cellosaurus logo
expasy logo

Cellosaurus 1321N1 MRTFA KO (CVCL_C3IQ)

[Text version]
Cell line name 1321N1 MRTFA KO
Synonyms 1321N1-MRTFA KO
Accession CVCL_C3IQ
Resource Identification Initiative To cite this cell line use: 1321N1 MRTFA KO (RRID:CVCL_C3IQ)
Comments Problematic cell line: Contaminated. Ancestral cell line (U-118MG) has been shown to be a U-138MG derivative.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14334; MRTFA.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0110 (1321N1)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=29887596; DOI=10.1038/s41388-018-0301-5; PMCID=PMC6195840
Olivia M. Yu, Jorge A. Benitez, Steven W. Plouffe, Daniel Ryback, Andrea Klein, Jeff Smith, Jason Greenbaum, Benjamin Delatte, Anjana Rao, Kun-Liang Guan, Frank B. Furnari ...Show all 14 authors... , Olga Meiri Chaim, Shigeki Miyamoto, Joan Heller Brown; Show fewer authors
YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.
Oncogene 37:5492-5507(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3IQ
Encyclopedic resources Wikidata; Q114310343
Gene expression databases GEO; GSM3034465
GEO; GSM3034466
GEO; GSM3034467
GEO; GSM3034468
GEO; GSM3034469
GEO; GSM3034470
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7