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Cellosaurus Jurkat (CVCL_0065)

[Text version]

Cell line name Jurkat
Synonyms JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024
Accession CVCL_0065
Resource Identification Initiative To cite this cell line use: Jurkat (RRID:CVCL_0065)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: International Histocompatibility Workshop cell lines.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: 26 hours (PubMed=17117183); ~25-35 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (PubMed=10739008; PubMed=11226526; PubMed=31068700; Sanger).
Omics: Acetylation analysis by proteomics.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Deep phosphoproteome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: HLA class I peptidome analysis by proteomics.
Omics: N-glycan profiling.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Ubiquitination analysis by proteomics.
Omics: Virome analysis using proteomics.
Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=352912).
Misspelling: JURKET; In PubMed=313568.
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (PubMed=9583678).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (PubMed=9583678).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (PubMed=19473701).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (PubMed=19473701).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (PubMed=9583678).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (PubMed=9510473).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Arg1627His (c.4880G>A); ClinVar=VCV000409067; Zygosity=Heterozygous (PubMed=15472075).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (PubMed=2144611; PubMed=10071127; PubMed=19220422; PubMed=22675565; Cosmic-CLP).
HLA typing Source: DSMZ
Class I
HLA-AA*03:01:01,03:01:01
HLA-BB*07:02:01,35:03:01
HLA-CC*04:01:01,07:02:01
Class II
HLA-DQDQB1*06:03:01,06:03:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.4
Native American0
East Asian, North0.13
East Asian, South1.21
South Asian1.08
European, North70.73
European, South26.45
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B7V8 (Abcam Jurkat CD1A KO)CVCL_B0Z5 (Abcam Jurkat CD1C KO)CVCL_B7V9 (Abcam Jurkat CD247 KO)
CVCL_B7VD (Abcam Jurkat IDH2 KO)CVCL_B0Z6 (Abcam Jurkat IFNG KO)CVCL_B0Z7 (Abcam Jurkat IKZF1 KO)
CVCL_B7VA (Abcam Jurkat LCK KO)CVCL_B7VB (Abcam Jurkat LEF1 KO)CVCL_B0Z8 (Abcam Jurkat PTPN2 KO)
CVCL_B7VF (Abcam Jurkat PVRIG KO)CVCL_B0Z9 (Abcam Jurkat TAL1 KO)CVCL_B7VE (Abcam Jurkat TP53 KO)
CVCL_B7VC (Abcam Jurkat ZAP70 KO)CVCL_U618 (BCL2 (AAA) Jurkat)CVCL_U619 (BCL2 (S70A) Jurkat)
CVCL_U620 (BCL2 (S87A) Jurkat)CVCL_U617 (BCL2 Jurkat)CVCL_KS58 (CellSensor CRE-bla Jurkat)
CVCL_KS63 (CellSensor ISRE-bla Jurkat)CVCL_KB42 (CellSensor NFAT-bla Jurkat)CVCL_KB43 (CellSensor NFkB-bla Jurkat)
CVCL_U426 (Flp-In-Jurkat)CVCL_ZK91 (GeneBLAzer CMV-bla Jurkat)CVCL_LB63 (GloResponse NFAT-RE-luc2 Jurkat)
CVCL_2461 (H33HJ-JA1)CVCL_U324 (J-A1886)CVCL_1H08 (J-Jhan)
CVCL_8281 (J-Lat 10.6)CVCL_8282 (J-Lat 15.4)CVCL_8280 (J-Lat 6.3)
CVCL_8284 (J-Lat 8.4)CVCL_8285 (J-Lat 9.2)CVCL_1H28 (J-Lat GFP Clone A72)
CVCL_1G41 (J-Lat Tat-GFP Clone 82)CVCL_1G42 (J-Lat Tat-GFP Clone A1)CVCL_1G43 (J-Lat Tat-GFP Clone A2)
CVCL_1G44 (J-Lat Tat-GFP Clone A7)CVCL_1G45 (J-Lat Tat-GFP Clone H2)CVCL_8279 (J1.1)
CVCL_R861 (J14)CVCL_B7PR (JcTaxWT-Neo7)CVCL_XF35 (JGFP1)
CVCL_1Y74 (JinB8)CVCL_2966 (JKT-beta-del)CVCL_4V24 (JL/AMSA)
CVCL_1E01 (JLTRG)CVCL_0D86 (JPX-9)CVCL_XF44 (JSL1)
CVCL_XF45 (JSL4)CVCL_IR10 (Jurkat 1G4)CVCL_1061 (Jurkat clone A3)
CVCL_3502 (Jurkat D1.1)CVCL_0367 (Jurkat E6.1)CVCL_4530 (Jurkat J6)
CVCL_KU30 (Jurkat KZ142 clone #24)CVCL_XZ57 (Jurkat NF-kb luciferase reporter)CVCL_YB71 (Jurkat pNFAT-EGFP)
CVCL_EG05 (Jurkat R3.25)CVCL_C3G2 (Jurkat RB1-KO)CVCL_KU38 (Jurkat Tet-Off)
CVCL_KU35 (Jurkat Tet-On)CVCL_V356 (Jurkat Tet-On 3G)CVCL_W813 (Jurkat tet-on clone 1)
CVCL_W814 (Jurkat tet-on clone 2)CVCL_0584 (Jurkat Wurzburg)CVCL_U326 (Jurkat-111)
CVCL_1G47 (Jurkat-522 F/Y)CVCL_1G48 (Jurkat-7/3 STOP)CVCL_6925 (Jurkat-77)
CVCL_U323 (Jurkat-99)CVCL_X703 (Jurkat-A2)CVCL_1G46 (Jurkat-deltaKS)
CVCL_X593 (Jurkat-Dual)CVCL_JZ99 (Jurkat-F9-1906LUC)CVCL_1F94 (Jurkat-HXBc2(4))
CVCL_1F95 (Jurkat-HXBc2(6))CVCL_B332 (Jurkat-JMN)CVCL_XX92 (Jurkat-LTRGT)
CVCL_B7NZ (Jurkat-Luc-RFP)CVCL_KS47 (Jurkat-Lucia NFAT)CVCL_C831 (Jurkat-TAg)
CVCL_X692 (Jurkat-tat)CVCL_AR84 (Jurkat/A4)CVCL_YJ84 (LINTERNA Jurkat)
CVCL_L807 (MDS)CVCL_8894 (MHH225)CVCL_U621 (Neo Jurkat)
CVCL_KZ68 (PathHunter Jurkat IkappaB Degradation)CVCL_1H23 (PPIA-/- Jurkat)CVCL_GY10 (UCDK9B1)
CVCL_GY11 (UCDK9B2)CVCL_GY12 (UCDK9B3)CVCL_GY13 (UCDK9B4)
CVCL_GY14 (UCDK9B5)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): CCRID; COG; Cosmic-CLP; DSMZ; ECACC; PubMed=28357668; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO9,10,11 (RCB_RCB0537)
10,11 (Cosmic-CLP; DSMZ)
10,12 (ECACC)
11 (RCB_RCB0806)
11,12 (CCRID; COG; PubMed=28357668; TKG)
D2S133819,23 (CCRID; COG)
19,23,24 (DSMZ)
D3S135815 (CCRID)
15,16,17 (COG; DSMZ)
15,17 (PubMed=28357668)
D5S8189
D7S8208,10 (CCRID; COG; ECACC; RCB_RCB0537; TKG)
8,10,11 (Cosmic-CLP; DSMZ; RCB_RCB0806)
8,12 (PubMed=28357668)
D8S117912,14,15 (COG)
13 (DSMZ)
13,14 (CCRID; PubMed=28357668)
D13S3178,10,11 (TKG)
8,11 (COG; Cosmic-CLP; DSMZ; ECACC; RCB_RCB0537)
8,11,12 (RCB_RCB0806)
8,12 (CCRID; PubMed=28357668)
D16S53910,11 (ECACC; RCB_RCB0537)
11 (CCRID; COG; Cosmic-CLP; DSMZ; PubMed=28357668; RCB_RCB0806; TKG)
D18S5113,14,20,21 (DSMZ)
13,21 (CCRID; PubMed=28357668)
D19S43313,15.2 (COG; PubMed=28357668)
13,16 (DSMZ)
14,15.2 (CCRID)
D21S1131.2,32.2 (COG)
31.2,33.2 (CCRID; PubMed=28357668)
31.2,32.2,33.2 (DSMZ)
FGA20,21 (CCRID; PubMed=28357668)
20,21,22 (DSMZ)
20,22 (COG)
Penta D11,13
Penta E9,10,12 (DSMZ)
10,12 (PubMed=28357668)
TH016,9.3
TPOX8,9,10 (RCB_RCB0537)
8,10 (CCRID; COG; Cosmic-CLP; DSMZ; ECACC; PubMed=28357668; RCB_RCB0806; TKG)
vWA16,17,18 (RCB_RCB0537; RCB_RCB0806)
16,17,19,20 (ECACC)
17,18,19 (COG)
17,18,19,20 (DSMZ)
18 (CCRID; PubMed=28357668)
18,19,20 (Cosmic-CLP)
18,20 (TKG)

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/Jurkat_cells
http://www.cells-talk.com/index.php/page/copelibrary?key=Jurkat
http://141.61.102.20/mxdb/project/show/9191407937500
http://genome.ucsc.edu/ENCODE/protocols/cell/human/Jurkat_protocol.pdf
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/j/cell-lines-detail-7.html
Publications

PubMed=1103999; DOI=10.1007/BF01634146
Schwenk H.-U., Schneider U.
Cell cycle dependency of a T-cell marker on lymphoblasts.
Blut 31:299-306(1975)

PubMed=1086134
Kaplan J., Peterson W.D. Jr.
Detection of T-cell lymphoma-associated antigens on cord blood lymphocytes and phytohemagglutinin-stimulated blasts.
Cancer Res. 36:3471-3475(1976)

PubMed=68013; DOI=10.1002/ijc.2910190505
Schneider U., Schwenk H.-U., Bornkamm G.-W.
Characterization of EBV-genome negative 'null' and 'T' cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma.
Int. J. Cancer 19:621-626(1977)

PubMed=204546; DOI=10.1007/978-3-642-66639-1_32
Schneider U., Schwenk H.-U.
Characterization of 'T' and 'non-T' cell lines established from children with acute lymphoblastic leukemia and non-Hodgkin lymphoma after leukemic transformation.
Haematol. Blood Transfus. 20:265-269(1977)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=3165345
LaGree K.A., Lee A.T., Stetten G., Strauss P.R.
The human Jurkat (FHCRC-11) cell line is heterogeneous in ploidy and cell size and releases detergent-soluble DNA.
Exp. Hematol. 16:686-690(1988)

PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990
Cheng J., Haas M.
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Mol. Cell. Biol. 10:5502-5509(1990)

PubMed=1915666; DOI=10.1016/0014-4827(91)90482-A
Limouse M., Manie S., Konstantinova I., Ferrua B., Schaffar L.
Inhibition of phorbol ester-induced cell activation in microgravity.
Exp. Cell Res. 197:82-86(1991)

PubMed=8127147
Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Borgonovo Brandter L., Heyman M., Rasool O., Liu Y., Grander D., Einhorn S.
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x
Kawasaki N., Matsuo Y., Yoshino T., Yanai H., Oka T., Teramoto N., Liu C., Kondo E., Minowada J., Akagi T.
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Jpn. J. Cancer Res. 87:1070-1077(1996)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9583678; DOI=10.1038/sj.onc.1201704
Brimmell M., Mendiola R., Mangion J., Packham G.
BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability.
Oncogene 16:1803-1812(1998)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=9787181; DOI=10.1182/blood.V92.9.3410
Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.
PTEN gene alterations in lymphoid neoplasms.
Blood 92:3410-3415(1998)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Kawamura M., Ohnishi H., Guo S.X., Sheng X.-M., Minegishi M., Hanada R., Horibe K., Hongo T., Kaneko Y., Bessho F., Yanagisawa M., Sekiya T., Hayashi Y.
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000),255-262.
Leuk. Res. 25:275-278(2001)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Kamimura K., Hojo H., Abe M.
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17117183; DOI=10.1038/sj.bjc.6603447
Beesley A.H., Palmer M.-L., Ford J., Weller R.E., Cummings A.J., Freitas J.R., Firth M.J., Perera K.U., de Klerk N.H., Kees U.R.
Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.
Br. J. Cancer 95:1537-1544(2006)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., de Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Kamihira S., Terada C., Sasaki D., Yanagihara K., Tsukasaki K., Hasegawa H., Yamada Y.
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19473701; DOI=10.1016/j.leukres.2009.04.032
Lo T.C.T., Barnhill L.M., Kim Y., Nakae E.A., Yu A.L.-T., Diccianni M.B.
Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing.
Leuk. Res. 33:1562-1566(2009)

PubMed=19608861; DOI=10.1126/science.1175371
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science 325:834-840(2009)

PubMed=22278370; DOI=10.1074/mcp.M111.014050
Geiger T., Wehner A., Schaab C., Cox J., Mann M.
Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins.
Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Atak Z.K., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=22944676; DOI=10.1515/hsz-2012-0195
Reinke S.O., Bayer M., Berger M., Hinderlich S., Blanchard V.
The analysis of N-glycans of cell membrane proteins from human hematopoietic cell lines reveals distinctions in their pattern.
Biol. Chem. 393:731-747(2012)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24618588; DOI=10.1371/journal.pone.0091433
Chernobrovkin A.L., Zubarev R.A.
Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins.
PLoS ONE 9:E91433-E91433(2014)

PubMed=26074081; DOI=10.1016/j.celrep.2015.05.029
Giansanti P., Aye T.T., van den Toorn H., Peng M., van Breukelen B., Heck A.J.R.
An augmented multiple-protease-based human phosphopeptide atlas.
Cell Rep. 11:1834-1843(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28357668; DOI=10.1007/978-1-4939-6872-5_11
Raimondi V., Minuzzo S., Ciminale V., D'Agostino D.M.
STR profiling of HTLV-1-infected cell lines.
Methods Mol. Biol. 1582:143-154(2017)

PubMed=29967540; DOI=10.1038/s41594-018-0084-y
Akimov V., Barrio-Hernandez I., Hansen S.V.F., Hallenborg P., Pedersen A.-K., Bekker-Jensen D.B., Puglia M., Christensen S.D.K., Vanselow J.T., Nielsen M.M., Kratchmarova I., Kelstrup C.D., Olsen J.V., Blagoev B.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites.
Nat. Struct. Mol. Biol. 25:631-640(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

PubMed=30844424; DOI=10.1016/j.humimm.2019.03.001
Creary L.E., Guerra S.G., Chong W., Brown C.J., Turner T.R., Robinson J., Bultitude W.P., Mayor N.P., Marsh S.G.E., Saito K., Lam K., Duke J.L., Mosbruger T.L., Ferriola D., Monos D.S., Willis A., Askar M., Fischer G.F., Saw C.L., Ragoussis J., Petrek M., Serra-Pages C., Juan Otero M., Stavropoulos-Giokas C., Dinou A., Ameen R., Al Shemmari S., Spierings E., Gendzekhadze K., Morris G.P., Zhang Q.-H., Kashi Z., Hsu S., Gangavarapu S., Mallempati K.C., Yamamoto F., Osoegawa K., Vayntrub T., Chang C.-J., Hansen J.A., Fernandez-Vina M.A.
Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.
Hum. Immunol. 80:449-460(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections Abcam; ab271143
Abcam; ab275468
CLS; 305018
DSMZ; ACC-282
ECACC; 86010201
HIVReagentProgram; ARP-4668
IBRC; C10155
ICLC; HTL01002 - Discontinued
IZSLER; BS CL 131
KCB; KCB 94018YJ
NCBI_Iran; C120
RCB; RCB0537
RCB; RCB0806
RCB; RCB3052
TKG; TKG 0209
Cell line databases/resources CLO; CLO_0007029
CLO; CLO_0007043
CLO; CLO_0050978
CLO; CLO_0050993
CLO; CLO_0051001
MCCL; MCC:0000503
CLDB; cl2950
CLDB; cl2959
CLDB; cl2960
CLDB; cl2961
CLDB; cl5212
CCRID; 1101HUM-PUMC000347
Cell_Model_Passport; SIDM01016
Cosmic-CLP; 998184
DepMap; ACH-000995
DSMZCellDive; ACC-282
IHW; IHW00002
LINCS_LDP; LCL-2107
Lonza; 142
TOKU-E; 3710
Anatomy/cell type resources BTO; BTO:0000661
Biological sample resources BioSample; SAMN03472181
BioSample; SAMN03472286
BioSample; SAMN03473341
BioSample; SAMN10988565
Chemistry resources ChEMBL-Cells; CHEMBL3307526
ChEMBL-Targets; CHEMBL397
GDSC; 998184
PharmacoDB; JURKAT_712_2019
PubChem_Cell_line; CVCL_0065
Encyclopedic resources Wikidata; Q1632589
Experimental variables resources EFO; EFO_0002796
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1991
GEO; GSM236783
GEO; GSM236819
GEO; GSM482494
GEO; GSM749672
GEO; GSM887188
GEO; GSM888261
GEO; GSM1040307
GEO; GSM1040377
GEO; GSM1374580
GEO; GSM1669965
GEO; GSM5137718
GEO; GSM5534218
GEO; GSM5534219
GEO; GSM5534220
GEO; GSM5534221
GEO; GSM5534222
GEO; GSM5534223
Medical resources MeSH; D019169
Polymorphism and mutation databases Cosmic; 683539
Cosmic; 721707
Cosmic; 755289
Cosmic; 801727
Cosmic; 850196
Cosmic; 913426
Cosmic; 919152
Cosmic; 922675
Cosmic; 933540
Cosmic; 991544
Cosmic; 998737
Cosmic; 999757
Cosmic; 1012072
Cosmic; 1037693
Cosmic; 1115592
Cosmic; 1118463
Cosmic; 1118464
Cosmic; 1127262
Cosmic; 1130236
Cosmic; 1132774
Cosmic; 1175129
Cosmic; 1191689
Cosmic; 1224368
Cosmic; 1226860
Cosmic; 1330489
Cosmic; 1375588
Cosmic; 1483364
Cosmic; 1524798
Cosmic; 1639637
Cosmic; 1641380
Cosmic; 1664522
Cosmic; 1760524
Cosmic; 1811157
Cosmic; 2039520
Cosmic; 2165713
Cosmic; 2301569
Cosmic; 2361366
Cosmic; 2602916
Cosmic; 2750872
IARC_TP53; 186
LiGeA; CCLE_029
Progenetix; CVCL_0065
Proteomic databases PRIDE; PRD000008
PRIDE; PRD000013
PRIDE; PXD000443
PRIDE; PRD000787
PRIDE; PXD000426
PRIDE; PXD001428
PRIDE; PXD001872
PRIDE; PXD002091
PRIDE; PXD002395
PRIDE; PXD006201
PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update15-Dec-2022
Version number40