| Cell line name |
J-Lat Tat-GFP Clone A1 |
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| Synonyms |
J-Lat tat-GFP A1 |
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| Accession |
CVCL_1G42 |
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| Resource Identification Initiative |
To cite this cell line use: J-Lat Tat-GFP Clone A1 (RRID:CVCL_1G42) |
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| Comments |
Population: Caucasian.
Virology: Latently infected with a GFP-tagged HIV-1 strain. The integrated HIV-1 genome is located in chromosome X (PubMed=28086908).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0065 (Jurkat) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=12682019; DOI=10.1093/emboj/cdg188; PMCID=PMC154479
Albert Jordan, Dwayne Bisgrove, Eric Verdin;
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.
EMBO J. 22:1868-1877(2003) PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Jori Symons, Abha Chopra, Eva Malatinkova, Ward De Spiegelaere, Shay Leary, Don Cooper, Chike O. Abana, Ajantha Rhodes, Simin D. Rezaei, Linos Vandekerckhove, Simon Mallal, Sharon Ruth Lewin, Paul Urquhart Cameron; Show fewer authors ...Show all 13 authors...
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017) |
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| Cross-references |
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| Cell line collections (Providers) |
BEI_Resources; ARP-9852
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| Cell line databases/resources |
cancercelllines; CVCL_1G42
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| Encyclopedic resources |
Wikidata; Q54898423
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| Entry history |
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| Entry creation | 08-Jul-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 19 |
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