ID   J-Lat Tat-GFP Clone A1
AC   CVCL_1G42
SY   J-Lat tat-GFP A1
DR   BEI_Resources; ARP-9852
DR   cancercelllines; CVCL_1G42
DR   Wikidata; Q54898423
RX   PubMed=12682019;
RX   PubMed=28086908;
CC   Population: Caucasian.
CC   Virology: Latently infected with a GFP-tagged HIV-1 strain. The integrated HIV-1 genome is located in chromosome X (PubMed=28086908).
CC   Sequence variation: Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0065 ! Jurkat
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 19
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RX   PubMed=12682019; DOI=10.1093/emboj/cdg188; PMCID=PMC154479;
RA   Jordan A., Bisgrove D., Verdin E.;
RT   "HIV reproducibly establishes a latent infection after acute infection
RT   of T cells in vitro.";
RL   EMBO J. 22:1868-1877(2003).
//
RX   PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276;
RA   Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S.,
RA   Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L.,
RA   Mallal S., Lewin S.R., Cameron P.U.;
RT   "HIV integration sites in latently infected cell lines: evidence of
RT   ongoing replication.";
RL   Retrovirology 14:2.1-2.11(2017).
//