Cellosaurus K562 NF-kappab-Luc2 reporter (CVCL_XZ57)
| Cell line name | K562 NF-kappab-Luc2 reporter |
|---|---|
| Synonyms | Jurkat NF-kb luciferase reporter |
| Accession | CVCL_XZ57 |
| Resource Identification Initiative | To cite this cell line use: K562 NF-kappab-Luc2 reporter (RRID:CVCL_XZ57) |
| Comments | Problematic cell line: Misidentified. Was originally thought to originate from the Jurkat cell line. STR profiling carried out at KYinno has shown it was derived from K-562. Be aware of this issue if you obtained this cell line before it was indicated as being derived from K-562. Population: Caucasian. Characteristics: The luciferase reporter gene is under the control of the NF-kappaB response element (KYinno=KC-0149). Doubling time: ~48 hours (KYinno=KC-0149). Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
| Sequence variations |
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| Disease | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110) Chronic myeloid leukemia (ORDO: Orphanet_521) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0004 (K-562) |
| Sex of cell | Female |
| Age at sampling | 53Y |
| Category | Cancer cell line |
| Cross-references | |
| Cell line collections (Providers) | KYinno; KC-0149 |
| Cell line databases/resources | cancercelllines; CVCL_XZ57 |
| Encyclopedic resources | Wikidata; Q94332884 |
| Entry history | |
| Entry creation | 19-Dec-2019 |
| Last entry update | 14-Aug-2025 |
| Version number | 14 |