Cell line name |
Jurkat D1.1 |
Synonyms |
D1.1; D1-1 |
Accession |
CVCL_3502 |
Resource Identification Initiative |
To cite this cell line use: Jurkat D1.1 (RRID:CVCL_3502) |
Comments |
Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10915. Population: Caucasian. Characteristics: CD4 negative subclone of Jurkat. Induces B cells to express surfac CD 23 molecules, a marker of B cell activation and to proliferate and terminally differentiate into Ig-secreting cells in the presence of T cell dependent B cell mitogens (PubMed=1834738). Omics: Variations; SNP array analysis. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0065 (Jurkat) |
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC=CRL-3600
Markers:Amelogenin | X |
CSF1PO | 11,12 |
D2S1338 | 19,23 |
D3S1358 | 13,15,16,17 |
D5S818 | 9 |
D7S820 | 8,10 |
D8S1179 | 12,13 |
D13S317 | 8,11 |
D16S539 | 10,11 |
D18S51 | 12,13,20,21 |
D19S433 | 13,14.2,15.2 |
D21S11 | 31.2,32.2,33.2,34.2 |
FGA | 19,20,21 |
Penta D | 11,13 |
Penta E | 10,12 |
TH01 | 6,9.3 |
TPOX | 8,10 |
vWA | 18,19,20 |
Run an STR similarity search on this cell line |
Web pages |
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=D1.1 Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/d1-1/ |
Publications | PubMed=1834738; DOI=10.4049/jimmunol.147.10.3389 Michael Jay Yellin, Julie J. Lee, Leonard Chess, Seth Lederman; A human CD4- T cell leukemia subclone with contact-dependent helper function. J. Immunol. 147:3389-3395(1991) Patent=US6331433 Seth Lederman, Leonard Chess, Michael Jay Yellin; Human T cell leukemia cell line designated D1.1. Patent number US6331433, 18-Dec-2001 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) |
Cross-references |
Cell line collections (Providers) |
ATCC; CRL-3600
ATCC; CRL-10915 - Discontinued
|
Cell line databases/resources |
CLO; CLO_0002658
cancercelllines; CVCL_3502
|
Biological sample resources |
BioSample; SAMN03471307
|
Encyclopedic resources |
Wikidata; Q54899131
|
Gene expression databases |
GEO; GSM827149
|
Polymorphism and mutation databases |
Cosmic; 683659
Progenetix; CVCL_3502
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 10-Apr-2025 |
Version number | 29 |
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