| Cell line name |
JLTRG |
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| Synonyms |
JLTR-RS; Jurkat LTR-GFP |
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| Accession |
CVCL_1E01 |
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| Resource Identification Initiative |
To cite this cell line use: JLTRG (RRID:CVCL_1E01) |
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| Comments |
Population: Caucasian.
Virology: Reporter cell line that expresses eGFP as a direct and quantitative marker of HIV-1 infection. The expression of eGFP is under the control of a HIV-1 LTR.
Doubling time: 24-48 hours (BEI_Resources=ARP-11587).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0065 (Jurkat)
Children:
|
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=15105117; DOI=10.1128/AAC.48.5.1652-1663.2004; PMCID=PMC400550
Olaf Kutsch, David N. Levy, Paula J. Bates, Julie Decker, Barry R. Kosloff, George M. Shaw, Waldemar Priebe, Etty N. Benveniste;
Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription.
Antimicrob. Agents Chemother. 48:1652-1663(2004) PubMed=16454046; DOI=10.2144/000112072
Christina Ochsenbauer-Jambor, Jennifer Jones, Marintha Heil, Kenneth Paul Zammit, Olaf Kutsch;
T-cell line for HIV drug screening using EGFP as a quantitative marker of HIV-1 replication.
BioTechniques 40:91-100(2006) |
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| Cross-references |
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| Cell line collections (Providers) |
BEI_Resources; ARP-11587
|
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| Cell line databases/resources |
cancercelllines; CVCL_1E01
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| Encyclopedic resources |
Wikidata; Q54898984
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| Entry history |
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| Entry creation | 08-Jul-2015 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 22 |
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