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Cellosaurus C11 (CVCL_C8ZJ)

[Text version]
Cell line name C11
Accession CVCL_C8ZJ
Resource Identification Initiative To cite this cell line use: C11 (RRID:CVCL_C8ZJ)
Comments Population: Caucasian.
Virology: Latently infected with the HIV-1 pseudovirus NL4-3-EGFP where the expression of EGFP is under the control of the HIV-1 LTR. The HIV-1 genome is singly integrated at 16p13.3 (PubMed=23804764).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Omics: CRISPR phenotypic screen.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=23804764; DOI=10.1093/nar/gkt571
Qu X.-Y., Wang P.-F., Ding D.-L., Li L., Wang H.-B., Ma L., Zhou X., Liu S.-H., Lin S.-G., Wang X.-H., Zhang G.-M., Liu S.-J., Liu L., Wang J.-H., Zhang F., Lu D.-R., Zhu H.-Z.
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells.
Nucleic Acids Res. 41:7771-7782(2013)

PubMed=32924251; DOI=10.15252/embr.201949305
Yang X.-Y., Wang Y.-N., Lu P.-P., Shen Y.-Z., Zhao X.-Y., Zhu Y.-Q., Jiang Z.-T., Yang H., Pan H.-Y., Zhao L., Zhong Y.-C., Wang J., Liang Z.-M., Shen X.-T., Lu D.-R., Jiang S.-B., Xu J.-Q., Wu H., Lu H.-Z., Jiang G.-C., Zhu H.-Z.
PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-kappaB signaling.
EMBO Rep. 21:e49305.1-e49305.13(2020)

Cross-references
CRISP screens repositories BioGRID_ORCS_Cell_line; 1385
Encyclopedic resources Wikidata; Q123030836
Entry history
Entry creation05-Oct-2023
Last entry update30-Jan-2024
Version number2