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Cellosaurus Jurkat C11 (CVCL_C8ZJ)

[Text version]
Cell line name Jurkat C11
Synonyms C11
Accession CVCL_C8ZJ
Resource Identification Initiative To cite this cell line use: Jurkat C11 (RRID:CVCL_C8ZJ)
Comments Population: Caucasian.
Virology: Latently infected with the HIV-1 pseudovirus NL4-3-EGFP where the expression of EGFP is under the control of the HIV-1 LTR. The HIV-1 genome is singly integrated at 16p13.3 (PubMed=23804764).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Omics: Phenotyping; CRISPR screening.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=23804764; DOI=10.1093/nar/gkt571; PMCID=PMC3763554
Xi-Ying Qu, Peng-Fei Wang, Dong-Lin Ding, Lin Li, Hai-Bo Wang, Li Ma, Xin Zhou, Shao-Hui Liu, Shi-Guan Lin, Xiao-Hui Wang, Gong-Min Zhang ...Show all 17 authors... , Si-Jie Liu, Lin Liu, Jian-Hua Wang, Feng Zhang, Da-Ru Lu, Huan-Zhang Zhu; Show fewer authors
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells.
Nucleic Acids Res. 41:7771-7782(2013)

PubMed=32924251; DOI=10.15252/embr.201949305; PMCID=PMC7645261
Xin-Yi Yang, Ya-Nan Wang, Pan-Pan Lu, Yin-Zhong Shen, Xia-Ying Zhao, Yu-Qi Zhu, Zheng-Tao Jiang, He Yang, Han-Yu Pan, Lin Zhao, Yang-Cheng Zhong ...Show all 21 authors... , Jing Wang, Zhi-Ming Liang, Xiao-Ting Shen, Da-Ru Lu, Shi-Bo Jiang, Jian-Qing Xu, Hao Wu, Hong-Zhou Lu, Guo-Chun Jiang, Huan-Zhang Zhu; Show fewer authors
PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-kappaB signaling.
EMBO Rep. 21:e49305.1-e49305.13(2020)

Cross-references
CRISP screens repositories BioGRID_ORCS_Cell_line; 1385
Encyclopedic resources Wikidata; Q123030836
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number6