| Cell line name |
Jurkat/A4 |
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| Synonyms |
Jurkat-A4 |
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| Accession |
CVCL_AR84 |
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| Resource Identification Initiative |
To cite this cell line use: Jurkat/A4 (RRID:CVCL_AR84) |
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| Comments |
Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0065 (Jurkat) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | CLPUB00316
Sokolovskaya A.A., Zabotina T.N., Blokhin D.Y., Inshakov A.N., Mikhailov A.D., Kadagidze Z.G., Baryshnikov A.Y.
CD95-deficient cells of Jurkat/A4 subline are resistant to drug-induced apoptosis.
Exp. Oncol. 23:175-180(2001) PubMed=20693966
Philchenkov A., Zavelevich M., Savinska L., Blokhin D.Y.
Jurkat/A4 cells with multidrug resistance exhibit reduced sensitivity to quercetin.
Exp. Oncol. 32:76-80(2010) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_AR84
|
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| Encyclopedic resources |
Wikidata; Q54899163
|
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| Entry history |
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| Entry creation | 02-May-2016 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 16 |
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