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Cellosaurus H33HJ-JA1 (CVCL_2461)

[Text version]
Cell line name H33HJ-JA1
Accession CVCL_2461
Resource Identification Initiative To cite this cell line use: H33HJ-JA1 (RRID:CVCL_2461)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8163.
Population: Caucasian.
Omics: Variations; SNP array analysis.
Misspelling: H33Hj-A1; KCB=KCB 2016015YJ.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-8163

Markers:
AmelogeninX,Y
CSF1PO11
D5S8189
D7S8208,10
D13S3178,10,11
D16S53911,12
TH016,9.3
TPOX8,10
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=7592872; DOI=10.1074/jbc.270.44.26533
Joseph Fargnoli, Anne L. Burkhardt, Maureen Laverty, Stephanie A. Kut, Nicolai S.C. van Oers, Arthur Weiss, Joseph B. Bolen;
Syk mutation in Jurkat E6-derived clones results in lack of p72syk expression.
J. Biol. Chem. 270:26533-26537(1995)

Patent=US5597901
Alvin S. Stern;
Homogeneous human interleukin 2.
Patent number US5597901, 28-Jan-1997

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-8163
ECACC; 90112119
KCB; KCB 2016015YJ
Cell line databases/resources CLO; CLO_0003593
CLDB; cl1542
cancercelllines; CVCL_2461
CCRID; 5301HUM-KCB16015YJ
LINCS_LDP; LCL-2037
Biological sample resources BioSample; SAMN03471197
Encyclopedic resources Wikidata; Q54872070
Gene expression databases GEO; GSM827363
Polymorphism and mutation databases Cosmic; 683537
IARC_TP53; 21354
Progenetix; CVCL_2461
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29