Cell line name |
J-Lat Tat-GFP Clone H2 |
Accession |
CVCL_1G45 |
Resource Identification Initiative |
To cite this cell line use: J-Lat Tat-GFP Clone H2 (RRID:CVCL_1G45) |
Comments |
Population: Caucasian. Virology: Latently infected with a GFP-tagged HIV-1 strain. The integrated HIV-1 genome is located in gene SLC25A12 (PubMed=28086908). Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0065 (Jurkat) |
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
Publications | PubMed=12682019; DOI=10.1093/emboj/cdg188; PMCID=PMC154479 Albert Jordan, Dwayne Bisgrove, Eric Verdin; HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 22:1868-1877(2003) PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276 Jori Symons, Abha Chopra, Eva Malatinkova, Ward De Spiegelaere, Shay Leary, Don Cooper, Chike O. Abana, Ajantha Rhodes, Simin D. Rezaei, Linos Vandekerckhove, Simon Mallal ...Show all 13 authors... , Sharon Ruth Lewin, Paul Urquhart Cameron; Show fewer authors HIV integration sites in latently infected cell lines: evidence of ongoing replication. Retrovirology 14:2.1-2.11(2017) |
Cross-references |
Cell line collections (Providers) |
BEI_Resources; ARP-9855
|
Cell line databases/resources |
cancercelllines; CVCL_1G45
|
Encyclopedic resources |
Wikidata; Q54898426
|
Entry history |
Entry creation | 08-Jul-2015 |
Last entry update | 19-Dec-2024 |
Version number | 19 |
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