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Cellosaurus Neo Jurkat (CVCL_U621)

[Text version]
Cell line name Neo Jurkat
Accession CVCL_U621
Resource Identification Initiative To cite this cell line use: Neo Jurkat (RRID:CVCL_U621)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2898

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133819,23
D3S135815,17
D5S8189
D7S8208,12
D8S117913,14
D13S3178,12
D16S53911
D18S5113,21
D19S43314,15.2
D21S1131.2,33.2
FGA20,21
Penta D11,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18

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Publications

PubMed=10567572; DOI=10.1128/mcb.19.12.8469; PMCID=PMC84954
Kazuhito Yamamoto, Hidenori Ichijo, Stanley Joel Korsmeyer;
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.
Mol. Cell. Biol. 19:8469-8478(1999)

Cross-references
Cell line collections (Providers) ATCC; CRL-2898
Cell line databases/resources cancercelllines; CVCL_U621
Encyclopedic resources Wikidata; Q54930401
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number20