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Cellosaurus SK-BR-3 (CVCL_0033)

[Text version]
Cell line name SK-BR-3
Synonyms SK-Br-3; Sk-Br-3; SK BR 03; SKBR-3; SKBr-3; SK-BR3; SKBr3; SkBr3; SKBR3
Accession CVCL_0033
Resource Identification Initiative To cite this cell line use: SK-BR-3 (RRID:CVCL_0033)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Human Protein Atlas, Cell Atlas panel.
Part of: ICBP43 breast cancer cell line panel.
Part of: JWGray breast cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 808.
Population: Caucasian.
Doubling time: 37.4 hours (PubMed=24389870); ~30 hours (CLS=300333); ~2-3 days (DSMZ=ACC-736); 56.19 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (PubMed=23671654).
Omics: Genomics; ChIP-seq; H2BK120ub.
Omics: Genomics; ChIP-seq; H3K23ac.
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K36me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; ChIP-seq; H3K79me2.
Omics: Genomics; ChIP-seq; H3K9ac.
Omics: Genomics; ChIP-seq; H3K9me3.
Omics: Genomics; ChIP-seq; H4K8ac.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Glycomics; N-glycan profiling.
Omics: Proteomics.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Glycoproteome.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Exosome.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Anecdotal: Used in a study utilising the fruit fly's olfactory system to detect cancer cells (PubMed=24389870).
Misspelling: SKBR3B; PubMed=26378940.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,02:01
HLA-BB*14:02,39/50/55
HLA-CC*03:04,03:04
Class II
HLA-DQDQB1*02:02,06:04

Source: PubMed=26589293
Class I
HLA-AA*02:01,11:01
HLA-BB*14:02,35:21
HLA-CC*03:04,03:04
Class II
HLA-DQDQB1*06:04,06:04
HLA-DRDRB1*01:05,01:05

Source: IPD-IMGT/HLA=12368
Class II
HLA-DPDPB1*03:01
HLA-DRDRB1*13:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.7
Native American0
East Asian, North2.13
East Asian, South0
South Asian0.26
European, North63.89
European, South33.02
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_YJ92 (LINTERNA SK-BR-3)CVCL_A2GI (LR-SKBR3)CVCL_RA92 (SK-BR-3 shPARG)
CVCL_YJ28 (SK-BR-3 shWDR12-4)CVCL_C8WI (SK-BR-3-EGFP)CVCL_4V52 (SK-BR-3-LR)
CVCL_4Y11 (SK-BR-3-Luc [JCRB])CVCL_C8WJ (SK-BR-3-Luc [Ubigene])CVCL_B6Y6 (SK-BR-3/nab-P)
CVCL_C9CH (SK-BR-3/Cas9-hyg)CVCL_B7P8 (SK-BR-3/PacR)CVCL_A2FE (SKBR-3-OE)
CVCL_YX81 (SKBR3 A3)CVCL_EI04 (SKBR3-AZDRa)CVCL_EI05 (SKBR3-AZDRb)
CVCL_EI06 (SKBR3-AZDRc)CVCL_4V68 (SKBR3-LAP[r])CVCL_EI07 (SKBR3-LAPRa)
CVCL_EI08 (SKBR3-LAPRb)CVCL_LG17 (SKBR3-LR)CVCL_LG18 (SKBR3-NR)
CVCL_EQ69 (SKBR3-PR)CVCL_LG19 (SKBR3-TR)CVCL_B3MN (SKBR3/TDR)
CVCL_E1C7 (Ubigene SK-BR-3 SENP7 KO)CVCL_YJ71 (VAMPIRO SK-BR-3)
Originate from same individual CVCL_1074 ! AU565
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0006007/65; ATCC=HTB-30; CCRID; CLS=300333; DSMZ=ACC-736; KCLB=30030; MSKCC; PubMed=25877200; PubMed=28889351; RCB=RCB2132; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO12
D2S133820,25
D3S135817
D5S8189 (MSKCC)
9,12 (AddexBio=C0006007/65; ATCC=HTB-30; CCRID; CLS=300333; DSMZ=ACC-736; KCLB=30030; PubMed=25877200; PubMed=28889351; RCB=RCB2132; Technion Genomics Center)
D7S8209,12
D8S117911,12 (CLS=300333)
12 (ATCC=HTB-30; CCRID; DSMZ=ACC-736; MSKCC; PubMed=25877200; Technion Genomics Center)
D13S31711 (Technion Genomics Center)
11,12 (AddexBio=C0006007/65; ATCC=HTB-30; CCRID; CLS=300333; DSMZ=ACC-736; KCLB=30030; MSKCC; PubMed=25877200; PubMed=28889351; RCB=RCB2132)
D16S5399
D18S5110,13
D19S43314
D21S1130,30.2
FGA20
Penta D9,12
Penta E10,11
TH018,9
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/morphology-and-growth-of-sk-br-3-htb-30-cells
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/sk-br-3.htm
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-57.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/SKBR3
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-sk-br-3
Publications

DOI=10.1007/978-1-4757-1647-4_5
Jorgen Fogh, Germain L. Trempe;
New human tumor cell lines.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.115-159; Springer; New York; USA (1975)

PubMed=1013510; DOI=10.1007/978-3-642-81043-5_5
Germain L. Trempe;
Human breast cancer in culture.
Recent Results Cancer Res. 57:33-41(1976)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Marilyn S. Pollack, Socorro D. Heagney, Philip O. Livingston, Jorgen Fogh;
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=6401685; DOI=10.1007/BF02617989
David Michael Halton, Ward Davis Peterson Jr., Bharati Hukku;
Cell culture quality control by rapid isoenzymatic characterization.
In Vitro 19:16-24(1983)

PubMed=6500159; DOI=10.1159/000163283
Merrill Eric Gershwin, Daniel Lentz, Robert B. Owens;
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=1961733; DOI=10.1073/pnas.88.23.10657; PMCID=PMC52989
Ingo Bernard Runnebaum, Mahalakshmi Nagarajan, Marianne Bowman, Darya Soto, Saraswati Sukumar;
Mutations in p53 as potential molecular markers for human breast cancer.
Proc. Natl. Acad. Sci. U.S.A. 88:10657-10661(1991)

DOI=10.1016/B978-0-12-333530-2.50009-5
Albert Leibovitz;
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=9671407; DOI=10.1038/sj.onc.1201814
Kimberley J. Sweeney, Alexander Swarbrick, Robert Lyndsay Sutherland, Elizabeth A. Musgrove;
Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells.
Oncogene 16:2865-2878(1998)

PubMed=10862037; DOI=10.1002/1098-2264(200007)28:3<308::AID-GCC9>3.0.CO;2-B
Soili Kytola, Jaana Rummukainen, Ann Nordgren, Ritva Karhu, Filip Farnebo, Jorma J. Isola, Catharina Larsson;
Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping.
Genes Chromosomes Cancer 28:308-317(2000)

PubMed=10969801
Farahnaz Forozan, Eija H. Mahlamaki, Outi Monni, Yi-Dong Chen, Robin Veldman, Yuan Jiang, Gerald C. Gooden, Stephen P. Ethier, Anne H. Kallioniemi, Olli-Pekka Kallioniemi;
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Cancer Res. 60:4519-4525(2000)

PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781
Jeffrey M. Davidson, Kylie Louise Gorringe, Suet-Feung Chin, Beatrice Orsetti, C. Besret, Celine Courtay-Cahen, Ian Roberts, Charles Theillet, Carlos Caldas, Paul A.W. Edwards;
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=11343771; DOI=10.1016/S0165-4608(00)00387-3
Jaana Rummukainen, Soili Kytola, Ritva Karhu, Filip Farnebo, Catharina Larsson, Jorma J. Isola;
Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping.
Cancer Genet. Cytogenet. 126:1-7(2001)

PubMed=12800145; DOI=10.1002/gcc.10218
Jose Adelaide, Huai-En Huang, Anne Murati, Amber E. Alsop, Beatrice Orsetti, Marie-Joelle Mozziconacci, Cornel Popovici, Christophe Ginestier, Anne Letessier, Celine Basset, Celine Courtay-Cahen ...Show all 16 authors... , Jocelyne Jacquemier, Charles Theillet, Daniel Birnbaum, Paul A.W. Edwards, Max Chaffanet; Show fewer authors
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Fons Elstrodt, Antoinette Hollestelle, Jord H.A. Nagel, Michael Gorin, Marijke Wasielewski, Ans M.W. van den Ouweland, Sofia Diana Merajver, Stephen P. Ethier, Mieke Schutte;
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16417655; DOI=10.1186/bcr1370; PMCID=PMC1413994
Ashleen Shadeo, Wan L. Lam;
Comprehensive copy number profiles of breast cancer cell model genomes.
Breast Cancer Res. 8:R9.1-R9.14(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Marijke Wasielewski, Fons Elstrodt, Jan G.M. Klijn, Els M.J.J. Berns, Mieke Schutte;
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521
Richard M. Neve, Koei Chin, Jane Fridlyand, Jennifer Yeh, Frederick L. Baehner, Tea Fevr, Laura Clark, Nora Bayani, Jean-Philippe Coppe, Frances Tong, Terry Speed ...Show all 27 authors... , Paul T. Spellman, Sandy DeVries, Anna Lapuk, Nick J. Wang, Wen-Lin Kuo, Jackie L. Stilwell, Daniel Pinkel, Donna G. Albertson, Frederic M. Waldman, Frank McCormick, Robert Brent Dickson, Michael D. Johnson, Marc E. Lippman, Stephen P. Ethier, Adi F. Gazdar, Joe W. Gray; Show fewer authors
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=17334996; DOI=10.1002/gcc.20438
Goran Jonsson, Johan Staaf, Eleonor Olsson, Markus Heidenblad, Johan Vallon-Christersson, Kazutoyo Osoegawa, Pieter J. de Jong, Stina M. Oredsson, Markus Ringner, Mattias Hoglund, Ake Borg;
High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization.
Genes Chromosomes Cancer 46:543-558(2007)

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005
Paraic A. Kenny, Genee Y. Lee, Connie A. Myers, Richard M. Neve, Jeremy R. Semeiks, Paul T. Spellman, Kristina Lorenz, Eva H. Lee, Mary Helen Barcellos-Hoff, Ole William Petersen, Joe W. Gray, Mina J. Bissell;
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
Mol. Oncol. 1:84-96(2007)

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084
Jessica Kao, Keyan Salari, Melanie Bocanegra, Yoon-La Choi, Luc Girard, Jeet Gandhi, Kevin A. Kwei, Tina Hernandez-Boussard, Pei Wang, Adi F. Gazdar, John D. Minna, Jonathan R. Pollack;
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:e6146.1-e6146.16(2009)

PubMed=19727395; DOI=10.1371/journal.pone.0006888; PMCID=PMC2731225
Raymond Couric Wadlow, Ben S. Wittner, S. Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen P. Finn, Massimo Loda, Umar Mahmood, Sridhar Ramaswamy;
Systems-level modeling of cancer-fibroblast interaction.
PLoS ONE 4:e6888.1-e6888.10(2009)

DOI=10.25904/1912/1434
Brian J. Morrison;
Breast cancer stem cells: tumourspheres and implications for therapy.
Thesis PhD (2010); Griffith University; Brisbane; Australia

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Antoinette Hollestelle, Jord H.A. Nagel, Marcel Smid, Suzanne Lam, Fons Elstrodt, Marijke Wasielewski, Ser Sue Ng, Pim J. French, Justine K. Peeters, Marieke J. Rozendaal, Muhammad Riaz ...Show all 26 authors... , Daphne G. Koopman, Timo L.M. ten Hagen, Bertie H.C.G.M. de Leeuw, Ellen C. Zwarthoff, Amina F.A.S. Teunisse, Peter J. van der Spek, Jan G.M. Klijn, Winand N.M. Dinjens, Stephen P. Ethier, Hans Cornelius Clevers, Aart G. Jochemsen, Michael A. den Bakker, John A. Foekens, John W.M. Martens, Mieke Schutte; Show fewer authors
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=20070913; DOI=10.1186/1471-2407-10-15; PMCID=PMC2836299
Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano, Kohsuke Sasaki;
Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: comparison of the CGH profiles between cancer cell lines and primary cancer tissues.
BMC Cancer 10:15.1-15.10(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20407441; DOI=10.1038/sj.bjc.6605671; PMCID=PMC2869170
Ivana Peran, Anna T. Riegel, Yu-Hai Dai, Richard Schlegel, Xue-Feng Liu;
Is HPV-18 present in human breast cancer cell lines?
Br. J. Cancer 102:1549-1550(2010)

PubMed=21247443; DOI=10.1186/gb-2011-12-1-r6; PMCID=PMC3091304
Henrik Edgren, Astrid Murumagi, Sara Kangaspeska, Daniel Nicorici, Vesa Hongisto, Kristine Kleivi, Inga H. Rye, Sandra Nyberg, Maija Wolf, Anne-Lise Borresen-Dale, Olli-Pekka Kallioniemi;
Identification of fusion genes in breast cancer by paired-end RNA-sequencing.
Genome Biol. 12:R6.1-R6.13(2011)

PubMed=21378333
Christopher H.J. Ford, Maie Al-Bader, Bushra Al-Ayadhi, Issam Francis;
Reassessment of estrogen receptor expression in human breast cancer cell lines.
Anticancer Res. 31:521-527(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=23151021; DOI=10.1186/1471-2164-13-619; PMCID=PMC3546428
Anita Grigoriadis, Alan Mackay, Elodie Noel, Pei-Jun Wu, Rachael Natrajan, Jessica Frankum, Jorge Sergio Reis-Filho, Andrew Tutt;
Molecular characterisation of cell line models for triple-negative breast cancers.
BMC Genomics 13:619.1-619.14(2012)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Muhammad Riaz, Marijn T.M. van Jaarsveld, Antoinette Hollestelle, Wendy J.C. Prager-van der Smissen, Anouk A.J. Heine, Antonius W.M. Boersma, Jing-Jing Liu, Jean C.A. Helmijr, Bahar Ozturk, Marcel Smid, Erik A.C. Wiemer ...Show all 13 authors... , John A. Foekens, John W.M. Martens; Show fewer authors
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

PubMed=24009699; DOI=10.1371/journal.pone.0072704; PMCID=PMC3751845
Xia Liu, Huan Nie, Yu-Bao Zhang, Yuan-Fei Yao, Alaiyi Maitikabili, You-Peng Qu, Shu-Liang Shi, Cui-Ying Chen, Yu Li;
Cell surface-specific N-glycan profiling in breast cancer.
PLoS ONE 8:e72704.1-e72704.11(2013)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310
Luika A. Timmerman, Thomas Holton, Mariia Yuneva, Raymond J. Louie, Merce Padro, Anneleen Daemen, Min Hu, Denise A. Chan, Stephen P. Ethier, Laura J. van 't Veer, Kornelia Polyak ...Show all 13 authors... , Frank McCormick, Joe W. Gray; Show fewer authors
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Cancer Cell 24:450-465(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776
Aleix Prat, Olga Karginova, Joel S. Parker, Cheng Fan, Xia-Ping He, Lisa M. Bixby, J. Chuck Harrell, Erick Roman, Barbara Adamo, Melissa A. Troester, Charles M. Perou;
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=24389870; DOI=10.1038/srep03576; PMCID=PMC3880960
Martin Strauch, Alja Ludke, Daniel Munch, Thomas Laudes, Cosmas Giovanni Galizia, Eugenio Martinelli, Luca Lavra, Roberto Paolesse, Alessandra Ulivieri, Alexandro Catini, Rosamaria Capuano, Corrado Di Natale;
More than apples and oranges -- detecting cancer with a fruit fly's antenna.
Sci. Rep. 4:3576.1-3576.9(2014)

PubMed=24456987; DOI=10.1186/1755-8166-7-8; PMCID=PMC3914704
Milena Rondon-Lagos, Ludovica Verdun Di Cantogno, Caterina Marchio, Nelson Rangel, Cesar Payan-Gomez, Patrizia Gugliotta, Cristina Botta, Gianni Bussolati, Sandra R. Ramirez-Clavijo, Barbara Pasini, Anna Sapino;
Differences and homologies of chromosomal alterations within and between breast cancer cell lines: a clustering analysis.
Mol. Cytogenet. 7:8.1-8.14(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25892236; DOI=10.1016/j.celrep.2015.03.050; PMCID=PMC4425736
Robert T. Lawrence, Elizabeth M. Perez, Daniel Hernandez, Chris P. Miller, Kelsey M. Haas, Hanna Y. Irie, Su-In Lee, C. Anthony Blau, Judit Villen;
The proteomic landscape of triple-negative breast cancer.
Cell Rep. 11:630-644(2015)

PubMed=26055192; DOI=10.1021/acs.jproteome.5b00375
Paolo Cifani, Ufuk Kirik, Sofia Waldemarson, Peter James;
Molecular portrait of breast-cancer-derived cell lines reveals poor similarity with tumors.
J. Proteome Res. 14:2819-2827(2015)

PubMed=26378940; DOI=10.1021/acs.analchem.5b02586; PMCID=PMC7389820
David J. Clark, William E. Fondrie, Zhong-Ping Liao, Phyllis I. Hanson, Amy Fulton, Li Mao, Austin J. Yang;
Redefining the breast cancer exosome proteome by tandem mass tag quantitative proteomics and multivariate cluster analysis.
Anal. Chem. 87:10462-10469(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470; PMCID=PMC5557415
Ten-Yang Yen, Spencer Bowen, Roger Yen, Alexandra Piryatinska, Bruce A. Macher, Leslie C. Timpe;
Glycoproteins in claudin-low breast cancer cell lines have a unique expression profile.
J. Proteome Res. 16:1391-1400(2017)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Jodi M. Saunus, Chanel E. Smart, Jamie R. Kutasovic, Rebecca L. Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N. Rozali, Ana Cristina Vargas, Lynne E. Reid, Eva Lorsy, Sibylle Cocciardi ...Show all 23 authors... , Tatjana Seidens, Amy Ellen McCart Reed, Andrew J. Dalley, Leesa F. Wockner, Julie Johnson, Debina Sarkar, Marjan E. Askarian-Amiri, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R. Lakhani; Show fewer authors
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

PubMed=29273624; DOI=10.1101/gr.226019.117; PMCID=PMC5793780
Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Wen-Qian Li, Yuan-Xin Xi, Dana Richardson, Kendra L. Allton, Kaori Tanaka, Jing Li, Shino Murakami, Khandan Keyomarsi ...Show all 17 authors... , Mark T. Bedford, Xiao-Bing Shi, Wei Li, Michelle C. Barton, Sharon Yoder Roth Dent, W. Lee Kraus; Show fewer authors
Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.
Genome Res. 28:159-170(2018)

PubMed=29954844; DOI=10.1101/gr.231100.117; PMCID=PMC6071638
Maria Nattestad, Sara Goodwin, Karen Ng, Timour Baslan, Fritz J. Sedlazeck, Philipp Rescheneder, Tyler Garvin, Han Fang, James Gurtowski, Elizabeth Hutton, Elizabeth Tseng ...Show all 20 authors... , Chen-Shan Chin, Timothy Beck, Yogi Sundaravadanam, Melissa Kramer, Eric Antoniou, John Douglas McPherson, James Hicks, W. Richard McCombie, Michael C. Schatz; Show fewer authors
Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line.
Genome Res. 28:1126-1135(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32942617; DOI=10.3390/cancers12092630; PMCID=PMC7564044
Hye Jin Lee, Seungho Shin, Jinho Kang, Ki-Cheol Han, Yeul Hong Kim, Jeoung-Won Bae, Kyong Hwa Park;
HSP90 inhibitor, 17-DMAG, alone and in combination with lapatinib attenuates acquired lapatinib-resistance in ER-positive, HER2-overexpressing breast cancer cell line.
Cancers (Basel) 12:2630.1-2630.16(2020)

Cross-references
Cell line collections (Providers) AddexBio; C0006007/65
ATCC; HTB-30
BCRJ; 0226
CancerTools; 161911
CCTCC; GDC0286
CLS; 300333
DSMZ; ACC-736
IBRC; C10147
ICLC; HTL03005
IZSLER; BS TCL 156
KCB; KCB 200723YJ
KCLB; 30030
NCBI_Iran; C207
RCB; RCB2132 - Discontinued
TKG; TKG 0592 - Discontinued
Ubigene; YC-C048
Cell line databases/resources CLO; CLO_0009034
CLO; CLO_0037295
MCCL; MCC:0000424
CLDB; cl4310
CLDB; cl7143
cancercelllines; CVCL_0033
CCRID; 1101HUM-PUMC000085
CCRID; 3101HUMTCHu225
CCRID; 4201HUM-CCTCC00286
Cell_Model_Passport; SIDM00897
DepMap; ACH-000017
DSMZCellDive; ACC-736
IPD-IMGT/HLA; 12368
LINCS_HMS; 50057
LINCS_LDP; LCL-1475
Lonza; 70
SLKBase; 3618
TOKU-E; 3129
Anatomy/cell type resources BTO; BTO_0002419
Biological sample resources BioSample; SAMN01821597
BioSample; SAMN03471462
BioSample; SAMN10987910
CRISP screens repositories BioGRID_ORCS_Cell_line; 378
Chemistry resources ChEMBL-Cells; CHEMBL3308062
ChEMBL-Targets; CHEMBL613834
PharmacoDB; SKBR3_1383_2019
PubChem_Cell_line; CVCL_0033
Encyclopedic resources Wikidata; Q7390592
Experimental variables resources EFO; EFO_0001236
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-TABM-157
ArrayExpress; E-TABM-244
GEO; GSM69195
GEO; GSM73742
GEO; GSM115115
GEO; GSM149978
GEO; GSM149986
GEO; GSM149994
GEO; GSM152556
GEO; GSM152557
GEO; GSM152558
GEO; GSM152559
GEO; GSM154096
GEO; GSM154097
GEO; GSM154098
GEO; GSM154099
GEO; GSM154100
GEO; GSM154101
GEO; GSM154102
GEO; GSM154104
GEO; GSM154107
GEO; GSM155215
GEO; GSM170624
GEO; GSM170625
GEO; GSM170626
GEO; GSM170627
GEO; GSM170630
GEO; GSM170631
GEO; GSM170633
GEO; GSM170634
GEO; GSM183440
GEO; GSM183441
GEO; GSM186457
GEO; GSM186458
GEO; GSM217596
GEO; GSM274644
GEO; GSM274663
GEO; GSM344357
GEO; GSM344407
GEO; GSM350501
GEO; GSM378146
GEO; GSM421883
GEO; GSM481334
GEO; GSM590106
GEO; GSM595617
GEO; GSM783927
GEO; GSM827582
GEO; GSM844686
GEO; GSM844687
GEO; GSM845399
GEO; GSM847432
GEO; GSM847499
GEO; GSM887575
GEO; GSM888658
GEO; GSM1008913
GEO; GSM1038850
GEO; GSM1038851
GEO; GSM1038852
GEO; GSM1038853
GEO; GSM1038854
GEO; GSM1053720
GEO; GSM1172895
GEO; GSM1172989
GEO; GSM1214572
GEO; GSM1238124
GEO; GSM1264069
GEO; GSM1264074
GEO; GSM1264111
GEO; GSM1264116
GEO; GSM1374872
GEO; GSM1374873
GEO; GSM1374874
GEO; GSM1401659
GEO; GSM1661988
GEO; GSM1833627
GEO; GSM2258794
GEO; GSM2258795
GEO; GSM2258796
GEO; GSM2258797
GEO; GSM2258798
GEO; GSM2258799
GEO; GSM2258800
GEO; GSM2258801
GEO; GSM2258802
GEO; GSM2258803
GEO; GSM2258804
GEO; GSM2258805
GEO; GSM2258806
GEO; GSM2258807
GEO; GSM2258808
GEO; GSM2258809
GEO; GSM2258810
GEO; GSM2258811
GEO; GSM2258950
GEO; GSM2258951
GEO; GSM2258952
GEO; GSM7701439
GEO; GSM7701440
Polymorphism and mutation databases Cosmic; 687499
Cosmic; 755294
Cosmic; 759896
Cosmic; 871159
Cosmic; 894090
Cosmic; 897742
Cosmic; 904385
Cosmic; 921974
Cosmic; 923062
Cosmic; 934531
Cosmic; 944297
Cosmic; 979713
Cosmic; 991329
Cosmic; 997935
Cosmic; 1000127
Cosmic; 1010922
Cosmic; 1018478
Cosmic; 1044209
Cosmic; 1046958
Cosmic; 1129655
Cosmic; 1136357
Cosmic; 1176645
Cosmic; 1287914
Cosmic; 1289405
Cosmic; 1308997
Cosmic; 1434957
Cosmic; 1524342
Cosmic; 1571789
Cosmic; 1609462
Cosmic; 2036669
Cosmic; 2165013
Cosmic; 2301535
Cosmic; 2318379
Cosmic; 2361351
IARC_TP53; 580
LiGeA; CCLE_391
Progenetix; CVCL_0033
Proteomic databases PRIDE; PXD000691
PRIDE; PXD002053
PRIDE; PXD002057
PRIDE; PXD002281
PRIDE; PXD002486
PRIDE; PXD005390
PRIDE; PXD008222
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number48